SCG5
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{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.{{cite journal | vauthors = Lloyd RV, Jin L | title = Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas | journal = Diagnostic Molecular Pathology | volume = 3 | issue = 1 | pages = 38–45 | date = March 1994 | pmid = 8162254 | doi = 10.1097/00019606-199403010-00007 }}{{cite journal | vauthors = Taupenot L, Harper KL, O'Connor DT | title = The chromogranin-secretogranin family | journal = The New England Journal of Medicine | volume = 348 | issue = 12 | pages = 1134–49 | date = March 2003 | pmid = 12646671 | doi = 10.1056/NEJMra021405 }}{{cite journal | vauthors = Martens GJ | title = Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2 | journal = FEBS Letters | volume = 234 | issue = 1 | pages = 160–4 | date = July 1988 | pmid = 3134253 | doi = 10.1016/0014-5793(88)81324-3 | doi-access = free }} The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme.{{cite web | title = Entrez Gene: SCG5 secretogranin V (7B2 protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6447}}{{cite journal | vauthors = Mbikay M, Seidah NG, Chrétien M | title = Neuroendocrine secretory protein 7B2: structure, expression and functions | journal = The Biochemical Journal | volume = 357 | issue = Pt 2 | pages = 329–42 | date = July 2001 | pmid = 11439082 | pmc = 1221959 | doi = 10.1042/0264-6021:3570329 | url = http://www.biochemj.org/bj/357/0329/bj3570329.htm }} It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects.{{cite journal | vauthors = Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I |author-link5=Iris Lindberg| title = Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion | journal = The Journal of Biological Chemistry | volume = 275 | issue = 23 | pages = 17886–93 | date = June 2000 | pmid = 10749852 | doi = 10.1074/jbc.M000032200 | doi-access = free }} It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2{{cite journal | vauthors = Lindberg I, Tu B, Muller L, Dicksinson I | title = Cloning and functional analysis of C. elegans 7B2 | journal = DNA and Cell Biology | volume = 17 | issue = 8 | pages = 727–734 | date = August 1998 | pmid = 9726255 | doi = 10.1089/dna.1998.17.727| url = }} and then renamed Seven B Two (gene name sbt-1).{{cite journal | vauthors = Sieburth et al| title = Systematic analysis of genes required for synapse structure and function | journal = Nature | volume = 436 | issue = 7050 | pages = 510–517 | date = July 2005 | pmid= 16049479 | doi = 10.1038/nature03809| bibcode = 2005Natur.436..510S | s2cid = 4427397 | url = }} There is a Pfam entry for this protein: Secretogranin_V (PF05281).
References
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Further reading
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- {{cite journal | vauthors = Mbikay M, Seidah NG, Chrétien M | title = Neuroendocrine secretory protein 7B2: structure, expression and functions | journal = The Biochemical Journal | volume = 357 | issue = Pt 2 | pages = 329–42 | date = July 2001 | pmid = 11439082 | pmc = 1221959 | doi = 10.1042/0264-6021:3570329 }}
- {{cite journal | vauthors = Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M | title = The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man | journal = Biochemical and Biophysical Research Communications | volume = 174 | issue = 1 | pages = 156–62 | date = January 1991 | pmid = 1989596 | doi = 10.1016/0006-291X(91)90499-W }}
- {{cite journal | vauthors = Roebroek AJ, Dehaen MR, van Bokhoven A, Martens GJ, Marÿnen P, van den Berghe H, Van de Ven WJ | title = Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 50 | issue = 2–3 | pages = 158–60 | year = 1989 | pmid = 2776483 | doi = 10.1159/000132749 }}
- {{cite journal | vauthors = Benjannet S, Marcinkiewicz M, Falgueyret JP, Johnson DE, Seidah NG, Chrétien M | title = Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors | journal = Endocrinology | volume = 123 | issue = 2 | pages = 874–84 | date = August 1988 | pmid = 2840270 | doi = 10.1210/endo-123-2-874 }}
- {{cite journal | vauthors = Martens GJ | title = Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2 | journal = FEBS Letters | volume = 234 | issue = 1 | pages = 160–4 | date = July 1988 | pmid = 3134253 | doi = 10.1016/0014-5793(88)81324-3 | doi-access = free }}
- {{cite journal | vauthors = Brayton KA, Aimi J, Qiu H, Yazdanparast R, Ghatei MA, Polak JM, Bloom SR, Dixon JE | display-authors = 6 | title = Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein | journal = DNA | volume = 7 | issue = 10 | pages = 713–9 | date = December 1988 | pmid = 3234177 | doi = 10.1089/dna.1988.7.713 }}
- {{cite journal | vauthors = Marcinkiewicz M, Benjannet S, Falgueyret JP, Seidah NG, Schürch W, Verdy M, Cantin M, Chrétien M | display-authors = 6 | title = Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma | journal = Endocrinology | volume = 123 | issue = 2 | pages = 866–73 | date = August 1988 | pmid = 3293987 | doi = 10.1210/endo-123-2-866 }}
- {{cite journal | vauthors = Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M | title = CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles | journal = Brain Research | volume = 380 | issue = 2 | pages = 349–56 | date = August 1986 | pmid = 3530373 | doi = 10.1016/0006-8993(86)90233-7 | s2cid = 22326257 }}
- {{cite journal | vauthors = Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, Cantin M, Chrétien M | display-authors = 6 | title = Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus | journal = Archives of Biochemistry and Biophysics | volume = 225 | issue = 2 | pages = 525–34 | date = September 1983 | pmid = 6625600 | doi = 10.1016/0003-9861(83)90063-2 }}
- {{cite journal | vauthors = Benjannet S, Savaria D, Chrétien M, Seidah NG | title = 7B2 is a specific intracellular binding protein of the prohormone convertase PC2 | journal = Journal of Neurochemistry | volume = 64 | issue = 5 | pages = 2303–11 | date = May 1995 | pmid = 7722516 | doi = 10.1046/j.1471-4159.1995.64052303.x | s2cid = 7133644 }}
- {{cite journal | vauthors = Braks JA, Martens GJ | title = 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway | journal = Cell | volume = 78 | issue = 2 | pages = 263–73 | date = July 1994 | pmid = 7913882 | doi = 10.1016/0092-8674(94)90296-8 | s2cid = 24734254 }}
- {{cite journal | vauthors = Braks JA, Broers CA, Danger JM, Martens GJ | title = Structural organization of the gene encoding the neuroendocrine chaperone 7B2 | journal = European Journal of Biochemistry | volume = 236 | issue = 1 | pages = 60–7 | date = February 1996 | pmid = 8617287 | doi = 10.1111/j.1432-1033.1996.00060.x | doi-access = free }}
- {{cite journal | vauthors = Bourdeau I, Antonini SR, Lacroix A, Kirschner LS, Matyakhina L, Lorang D, Libutti SK, Stratakis CA | display-authors = 6 | title = Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators | journal = Oncogene | volume = 23 | issue = 8 | pages = 1575–85 | date = February 2004 | pmid = 14767469 | doi = 10.1038/sj.onc.1207277 | s2cid = 25336472 | doi-access = }}
- {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | display-authors = 6 | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | doi-access = free }}
- {{cite journal | vauthors = Dasgupta I, Sanglas L, Enghild JJ, Lindberg I | title = The neuroendocrine protein 7B2 is intrinsically disordered | journal = Biochemistry | volume = 51 | issue = 38 | pages = 7456–64 | date = September 2012 | pmid = 22947085 | pmc = 3457758 | doi = 10.1021/bi300871k }}
- {{cite journal | vauthors = Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, Eriksen JL, Lindberg I | display-authors = 6 | title = The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins | journal = The Journal of Biological Chemistry | volume = 288 | issue = 2 | pages = 1114–24 | date = January 2013 | pmid = 23172224 | pmc = 3542996 | doi = 10.1074/jbc.M112.417071 | doi-access = free }}
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{{Nerve tissue protein}}
{{gene-15-stub}}