Login
Login

SCGB1D2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

Secretoglobin family 1D member 2 is a protein that in humans is encoded by the SCGB1D2 gene.{{cite journal | vauthors = Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI | title = Lipophilins: human peptides homologous to rat prostatein | journal = Biochemical and Biophysical Research Communications | volume = 256 | issue = 1 | pages = 147–55 | date = March 1999 | pmid = 10066439 | doi = 10.1006/bbrc.1999.0274 }}{{cite journal | vauthors = Lehrer RI, Xu G, Abduragimov A, Dinh NN, Qu XD, Martin D, Glasgow BJ | title = Lipophilin, a novel heterodimeric protein of human tears | journal = FEBS Letters | volume = 432 | issue = 3 | pages = 163–7 | date = August 1998 | pmid = 9720917 | doi = 10.1016/S0014-5793(98)00852-7 | s2cid = 205880914 | doi-access = free | bibcode = 1998FEBSL.432..163L }}{{cite web | title = Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10647}}

Function

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.

SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells.{{cite journal | vauthors = Lacroix M | title = Significance, detection and markers of disseminated breast cancer cells | journal = Endocrine-Related Cancer | volume = 13 | issue = 4 | pages = 1033–67 | date = December 2006 | pmid = 17158753 | doi = 10.1677/ERC-06-0001 | publisher = Bioscientifica | doi-access = | s2cid = 10708900 }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Culleton J, O'Brien N, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ | title = Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer | journal = International Journal of Cancer | volume = 120 | issue = 5 | pages = 1087–92 | date = March 2007 | pmid = 17163411 | doi = 10.1002/ijc.22471 | s2cid = 20729571 | doi-access = free }}
  • {{cite journal | vauthors = Sjödin A, Guo D, Lund-Johansen M, Krossnes BK, Lilleng P, Henriksson R, Hedman H | title = Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas | journal = Acta Neuropathologica | volume = 109 | issue = 4 | pages = 381–6 | date = April 2005 | pmid = 15668787 | doi = 10.1007/s00401-004-0972-6 | s2cid = 20395605 }}
  • {{cite journal | vauthors = Carter D, Dillon DC, Reynolds LD, Retter MW, Fanger G, Molesh DA, Sleath PR, McNeill PD, Vedvick TS, Reed SG, Persing DH, Houghton RL | title = Serum antibodies to lipophilin B detected in late stage breast cancer patients | journal = Clinical Cancer Research | volume = 9 | issue = 2 | pages = 749–54 | date = February 2003 | pmid = 12576445 }}
  • {{cite journal | vauthors = Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS | title = Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer | journal = Biochemistry | volume = 41 | issue = 21 | pages = 6714–22 | date = May 2002 | pmid = 12022875 | doi = 10.1021/bi0159884 }}

{{refend}}

External links

  • [http://www.nextbio.com/b/home/home.nb?id=40477&type=feature&name=SCGB1D2 Microarray study results where SCGB1D2 is significantly up or downregulated]

{{gene-11-stub}}