Login
Login

SCN4B

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Infobox_gene}}

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.{{Cite journal | vauthors = Lewis AH, Raman IM | title = Resurgent current of voltage-gated Na+ channels | journal = The Journal of Physiology | volume = 592 | issue = 22 | pages = 4825–4838 | date = 2014-11-15 | pmid = 25172941 | pmc = 4259529 | doi = 10.1113/jphysiol.2014.277582 | language = en | issn = 1469-7793 }} The protein is encoded by the SCN4B gene.{{cite web | title = Entrez Gene: sodium channel | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6330 }} Mutations in the SCN4B are associated with long QT syndrome.{{cite journal | vauthors = Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ | title = SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome | journal = Circulation | volume = 116 | issue = 2 | pages = 134–142 | date = July 2007 | pmid = 17592081 | pmc = 3332546 | doi = 10.1161/CIRCULATIONAHA.106.659086 }}

SCN4B might additionally function as a cell adhesion molecule.{{cite journal | vauthors = Shimizu H | title = Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits | journal = Scientific Reports | volume = 6 | pages = 26618 | year = 2016 | pmid = 27216889 | pmc = 4877568 | doi = 10.1038/srep26618 | bibcode = 2016NatSR...626618S }}{{cite journal | vauthors = Shimizu H | title = Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion. | journal = J Biol Chem | volume = 27 | issue = 32 | pages = 13428–13440 | year = 2017 | pmid = 28655765 | pmc = 5555201 | doi = 10.1074/jbc.M117.786509 | doi-access = free }}

See also

References

{{Reflist}}

{{clear}}

Further reading

{{refbegin|30em}}

  • {{cite journal | vauthors = Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M | title = [Idiopathic thrombocytopenic purpura: present knowledge and future expectations] | journal = Sangre | volume = 37 | issue = 6 | pages = 449–456 | year = 1992 | pmid = 1293796 }}
  • {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, etal | title = Complete sequencing and characterization of 21,243 full-length human cDNAs. | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–45 | year = 2004 | pmid = 14702039 | doi = 10.1038/ng1285 | doi-access = free }}
  • {{cite journal | vauthors = Yu FH, Westenbroek RE, Silos-Santiago I, etal | title = Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. | journal = J. Neurosci. | volume = 23 | issue = 20 | pages = 7577–7585 | year = 2003 | pmid = 12930796 | pmc = 6740763 | doi = 10.1523/JNEUROSCI.23-20-07577.2003 | doi-access = free }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, etal | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Webb J, Wu FF, Cannon SC | title = Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit. | journal = Pflügers Arch. | volume = 457 | issue = 6 | pages = 1253–1263 | year = 2009 | pmid = 18941776 | pmc = 6207185 | doi = 10.1007/s00424-008-0600-8 }}
  • {{cite journal | vauthors = Shimizu H | title = Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits | journal = Scientific Reports | volume = 6 | pages = 26618 | year = 2016 | pmid = 27216889 | pmc = 4877568 | doi = 10.1038/srep26618 | bibcode = 2016NatSR...626618S }}

{{refend}}

External links

  • {{PDBe-KB2|Q8IWT1|Human Sodium channel subunit beta-4 (SCN4B)}}

Category:Sodium channels