SDK2

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.{{cite web | title = Entrez Gene: SDK2 sidekick homolog 2 (chicken)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54549}}

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• {{cite journal |title=Structure and Functions of Sidekicks|year=2020|doi=10.3389/fnmol.2020.00139|pmid=32982686|vauthors=Yamagata M |journal=Frontiers in Molecular Neuroscience|volume=13|page=139|pmc=7479261 |doi-access=free }}
• {{cite journal | vauthors = Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE | title = Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy | journal = J Am Soc Nephrol | volume = 15 | issue = 7 | pages = 1721–30 |date=Jun 2004 | pmid = 15213259 | doi =10.1097/01.ASN.0000128975.28958.C2 | doi-access = free }}
• {{cite journal |vauthors=Zody MC, Garber M, Adams DJ, etal |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage |journal=Nature |volume=440 |issue= 7087 |pages= 1045–9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 | pmc=2610434 |bibcode=2006Natur.440.1045Z }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 |doi-access=free }}
• {{cite journal | vauthors=Nguyen DN, Liu Y, Litsky ML, Reinke R |title=The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye |journal=Development |volume=124 |issue= 17 |pages= 3303–12 |year= 1997 |doi=10.1242/dev.124.17.3303 |pmid= 9310325 }}

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{{PDB Gallery|geneid=54549}}

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