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SEC23IP

{{Short description|Protein-coding gene in the species Homo sapiens}}

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SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.{{cite journal | vauthors = Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M | title = p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins | journal = J Biol Chem | volume = 274 | issue = 29 | pages = 20505–12 |date=Aug 1999 | pmid = 10400679 | doi =10.1074/jbc.274.29.20505 | doi-access = free }}{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196}}

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.{{cite web | title = Entrez Gene: SEC23IP SEC23 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11196}}

References

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Further reading

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  • {{cite journal |vauthors=Li H, Xie B, Zhou Y, etal |title=Functional roles of p12, the fourth subunit of human DNA polymerase delta. |journal=J. Biol. Chem. |volume=281 |issue= 21 |pages= 14748–55 |year= 2006 |pmid= 16510448 |doi= 10.1074/jbc.M600322200 |doi-access= free }}
  • {{cite journal |vauthors=Shimoi W, Ezawa I, Nakamoto K, etal |title=p125 is localized in endoplasmic reticulum exit sites and involved in their organization. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10141–8 |year= 2005 |pmid= 15623529 |doi= 10.1074/jbc.M409673200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Mizoguchi T, Nakajima K, Hatsuzawa K, etal |title=Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 1 |pages= 144–9 |year= 2001 |pmid= 11112430 |doi= 10.1006/bbrc.2000.3846 }}

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