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SEDLP

{{Short description|Pseudogene in the species Homo sapiens}}

{{Infobox_gene}}

Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene.{{cite web | title = Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10597}}

This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.{{cite web | title = Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10597}}

References

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Further reading

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  • {{cite journal | author=Sacher M |title=Membrane traffic fuses with cartilage development. |journal=FEBS Lett. |volume=550 |issue= 1–3 |pages= 1–4 |year= 2003 |pmid= 12935876 |doi=10.1016/S0014-5793(03)00854-8 |s2cid=7388750 |doi-access= |bibcode=2003FEBSL.550....1S }}
  • {{cite journal |vauthors=Gécz J, Hillman MA, Gedeon AK, etal |title=Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda |journal=Genomics |volume=69 |issue= 2 |pages= 242–51 |year= 2001 |pmid= 11031107 |doi= 10.1006/geno.2000.6326 }}
  • {{cite journal |vauthors=Ghosh AK, Majumder M, Steele R, etal |title=A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1 |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 655–62 |year= 2001 |pmid= 11134351 |doi= 10.1128/MCB.21.2.655-662.2001 | pmc=86643 }}
  • {{cite journal |vauthors=Venter JC, Adams MD, Myers EW, etal |title=The sequence of the human genome |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 |bibcode=2001Sci...291.1304V |doi-access= }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Ghosh AK, Steele R, Ray RB |title=Modulation of human luteinizing hormone beta gene transcription by MIP-2A |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 24033–8 |year= 2003 |pmid= 12700240 |doi= 10.1074/jbc.M211982200 |doi-access= free }}
  • {{cite journal | vauthors=Savarirayan R, Thompson E, Gécz J |title=Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400) |journal=Eur. J. Hum. Genet. |volume=11 |issue= 9 |pages= 639–42 |year= 2004 |pmid= 12939648 |doi= 10.1038/sj.ejhg.5201025 |doi-access= free }}
  • {{cite journal | vauthors=Gécz J, Shaw MA, Bellon JR, de Barros Lopes M |title=Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not |journal=Gene |volume=320 |pages= 137–44 |year= 2004 |pmid= 14597397 |doi=10.1016/S0378-1119(03)00819-9 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

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Category:Proteins