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SEMA4G

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Semaphorin-4G is a protein in humans encoded by the SEMA4G gene.{{cite web | title = Entrez Gene: SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57715}}

Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement.{{Cite journal |last=Kruger |first=Robert P. |last2=Aurandt |first2=Jennifer |last3=Guan |first3=Kun-Liang |date=October 2005 |title=Semaphorins command cells to move |url=https://www.nature.com/articles/nrm1740 |journal=Nature Reviews Molecular Cell Biology |language=en |volume=6 |issue=10 |pages=789–800 |doi=10.1038/nrm1740 |issn=1471-0080}}

Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.

References

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Further reading

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  • {{cite journal | vauthors=Pasterkamp RJ, Kolodkin AL |title=Semaphorin junction: making tracks toward neural connectivity |journal=Curr. Opin. Neurobiol. |volume=13 |issue= 1 |pages= 79–89 |year= 2003 |pmid= 12593985 |doi=10.1016/S0959-4388(03)00003-5 |s2cid=40661992 }}
  • {{cite journal | author=Dickson BJ |title=Molecular mechanisms of axon guidance |journal=Science |volume=298 |issue= 5600 |pages= 1959–64 |year= 2003 |pmid= 12471249 |doi= 10.1126/science.1072165 |s2cid=28328792 }}
  • {{cite book |vauthors=Holtmaat AJ, De Winter F, De Wit J, etal |chapter=Semaphorins: Contributors to structural stability of hippocampal networks? |title=Plasticity in the Adult Brain: From Genes to Neurotherapy |journal=Prog. Brain Res. |volume=138 |pages= 17–38 |year= 2002 |pmid= 12432760 |doi=10.1016/S0079-6123(02)38068-3 | series=Progress in Brain Research | isbn=978-0-444-50981-9 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M, etal |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|doi-access=free }}

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