SENP3

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene.{{cite journal | vauthors = Yeh ET, Gong L, Kamitani T | title = Ubiquitin-like proteins: new wines in new bottles | journal = Gene | volume = 248 | issue = 1–2 | pages = 1–14 |date=May 2000 | pmid = 10806345 | doi = 10.1016/S0378-1119(00)00139-6}}{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 |date=March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

SENP3 together with SENP5, belongs to the Ulp1 branch in yeast and localize to nucleolus through B23/NPM1. SENP3 is associated and regulated by B23/nucleophosmin/NPM1 and involved in the regulation of ribosome biogenesis. SENP3 may be regulated by Arf-Mdm2-p53 pathway.{{cite web | title = Entrez Gene: SENP3 SUMO1/sentrin/SMT3 specific peptidase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26168}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Yeh ET, Gong L, Kamitani T |title=Ubiquitin-like proteins: new wines in new bottles |journal=Gene |volume=248 |issue= 1–2 |pages= 1–14 |year= 2000 |pmid= 10806345 |doi=10.1016/S0378-1119(00)00139-6 }}
  • {{cite journal | vauthors=Nishida T, Tanaka H, Yasuda H |title=A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase |journal=Eur. J. Biochem. |volume=267 |issue= 21 |pages= 6423–7 |year= 2000 |pmid= 11029585 |doi=10.1046/j.1432-1327.2000.01729.x |doi-access=free }}
  • {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
  • {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
  • {{cite journal |vauthors=Bouras T, Fu M, Sauve AA, etal |title=SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10264–76 |year= 2005 |pmid= 15632193 |doi= 10.1074/jbc.M408748200 |doi-access= free }}
  • {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
  • {{cite journal | vauthors=Grégoire S, Yang XJ |title=Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors |journal=Mol. Cell. Biol. |volume=25 |issue= 6 |pages= 2273–87 |year= 2005 |pmid= 15743823 |doi= 10.1128/MCB.25.6.2273-2287.2005 | pmc=1061617 }}
  • {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
  • {{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |doi-access=free }}
  • {{cite journal | vauthors=Gong L, Yeh ET |title=Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 |journal=J. Biol. Chem. |volume=281 |issue= 23 |pages= 15869–77 |year= 2006 |pmid= 16608850 |doi= 10.1074/jbc.M511658200 |doi-access= free }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
  • {{cite journal |vauthors=Yun C, Wang Y, Mukhopadhyay D, etal |title=Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases |journal=J. Cell Biol. |volume=183 |issue= 4 |pages= 589–95 |year= 2008 |pmid= 19015314 |doi=10.1083/jcb.200807185 | pmc=2582899 }}
  • {{cite journal | vauthors = Haindl M, Harasim T, Eick D, Muller S | title = The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing | journal = EMBO Rep. | volume = 9 | issue = 3 | pages = 273–9 |date=March 2008 | pmid = 18259216 | doi = 10.1038/embor.2008.3 | pmc = 2267381 }}
  • {{cite journal |vauthors=Kuo ML, den Besten W, Thomas MC, etal |title=Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3 |journal=Cell Cycle |volume=7 |issue= 21 |pages= 3378–87 |year= 2008 |pmid= 18948745 | doi=10.4161/cc.7.21.6930|doi-access=free }}

{{refend}}

References

{{Reflist}}

{{gene-17-stub}}