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SERINC3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene.{{cite journal | vauthors = Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM | title = The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue | journal = Molecular Carcinogenesis | volume = 26 | issue = 3 | pages = 189–200 | date = November 1999 | pmid = 10559794 | doi = 10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T | s2cid = 19505445 }}{{cite web | title = Entrez Gene: SERINC3 serine incorporator 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10955}} It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. {{cite journal | vauthors = Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M | title = HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation | journal = Nature | volume = 526 | issue = 7572 | pages = 212–7 | date = October 2015 | pmid = 26416734 | doi = 10.1038/nature15399 | pmc = 4861059 | bibcode = 2015Natur.526..212R }}{{cite journal | vauthors = Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M | title = S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 113 | issue = 46 | pages = 13197–13202 | date = November 2016 | pmid = 27803322 | doi = 10.1073/pnas.1612044113 | pmc = 5135340 | doi-access = free }}{{cite journal | journal = bioRxiv |doi=10.1101/2020.02.24.962506 |title=Coevolution of retroviruses with SERINCs following whole-genome duplication divergence |last1=Ramdas |first1=Pavitra |last2=Bhardwaj |first2=Vipin |last3=Singh |first3=Aman |last4=Vijay |first4=Nagarjun |last5=Chande |first5=Ajit |date=2020-02-24 |doi-access=free }}

References

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Further reading

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  • {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | doi = | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Bossolasco M, Veillette F, Bertrand R, Mes-Masson AM | title = Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis | journal = Oncogene | volume = 25 | issue = 33 | pages = 4549–58 | date = August 2006 | pmid = 16547497 | doi = 10.1038/sj.onc.1209488 | doi-access = | s2cid = 24696947 }}

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