SESN3

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

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• {{cite journal |vauthors=Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue=7–8 |pages=247–53 |year=2010 |pmid=20379614 |pmc=2896464 |doi=10.2119/molmed.2009.00159 }}
• {{cite journal |vauthors=Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N |title=FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor |journal=Dev. Cell |volume=18 |issue=4 |pages=592–604 |year=2010 |pmid=20412774 |pmc=3031984 |doi=10.1016/j.devcel.2010.03.008 }}
• {{cite journal |vauthors=Zamkova M, Khromova N, Kopnin BP, Kopnin P |title=Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways |journal=Cell Cycle |volume=12 |issue=5 |pages=826–36 |year=2013 |pmid=23388456 |pmc=3610730 |doi=10.4161/cc.23723 }}
• {{cite journal |vauthors=Nascimento EB, Osler ME, Zierath JR |title=Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle |journal=Am. J. Physiol. Endocrinol. Metab. |volume=305 |issue=11 |pages=E1408–14 |year=2013 |pmid=24129397 |pmc=3882372 |doi=10.1152/ajpendo.00212.2013 }}
• {{cite journal |vauthors=Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC |title=Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells |journal=PLOS ONE |volume=8 |issue=11 |pages=e78780 |year=2013 |pmid=24260131 |pmc=3832611 |doi=10.1371/journal.pone.0078780 |bibcode=2013PLoSO...878780V |doi-access=free }}
• {{cite journal |vauthors=Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S |title=The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=307 |issue=1 |pages=G58–65 |year=2014 |pmid=24833709 |pmc=4080163 |doi=10.1152/ajpgi.00373.2013 }}

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