SFPQ
{{Short description|Non-coding RNA in the species Homo sapiens}}
{{Infobox_gene}}
Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.{{cite journal | vauthors = Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B | title = Cloning and characterization of PSF, a novel pre-mRNA splicing factor | journal = Genes & Development | volume = 7 | issue = 3 | pages = 393–406 | date = Mar 1993 | pmid = 8449401 | doi = 10.1101/gad.7.3.393 | doi-access = free }}{{cite web | title = Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6421}}
Interactions
SFPQ has been shown to interact with PTBP1,{{cite journal | vauthors = Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G | title = Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB | journal = Journal of Cellular Biochemistry | volume = 76 | issue = 4 | pages = 559–66 | date = Jan 2000 | pmid = 10653975 | doi = 10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U | s2cid = 25669908 }} NONO,{{cite journal | vauthors = Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG | title = PSF and p54nrb bind a conserved stem in U5 snRNA | journal = RNA | volume = 8 | issue = 10 | pages = 1334–47 | date = Oct 2002 | pmid = 12403470 | pmc = 1370341 | doi = 10.1017/S1355838202022070 }} CDC5L{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }} and Ubiquitin C.{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Shav-Tal Y, Zipori D | title = PSF and p54(nrb)/NonO--multi-functional nuclear proteins | journal = FEBS Letters | volume = 531 | issue = 2 | pages = 109–14 | date = Nov 2002 | pmid = 12417296 | doi = 10.1016/S0014-5793(02)03447-6 | s2cid = 12485304 | doi-access = free }}
- {{cite journal | vauthors = Gower HJ, Moore SE, Dickson G, Elsom VL, Nayak R, Walsh FS | title = Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody | journal = Development | volume = 105 | issue = 4 | pages = 723–31 | date = Apr 1989 | doi = 10.1242/dev.105.4.723 | pmid = 2480877 }}
- {{cite journal | vauthors = Gozani O, Patton JG, Reed R | title = A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3356–67 | date = Jul 1994 | pmid = 8045264 | pmc = 395233 | doi = 10.1002/j.1460-2075.1994.tb06638.x}}
- {{cite journal | vauthors = Zhang WW, Zhang LX, Busch RK, Farrés J, Busch H | title = Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells | journal = The Biochemical Journal | volume = 290 | issue = 1 | pages = 267–72 | date = Feb 1993 | pmid = 8439294 | pmc = 1132410 | doi = 10.1042/bj2900267}}
- {{cite journal | vauthors = Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS | title = Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma | journal = Oncogene | volume = 15 | issue = 18 | pages = 2233–9 | date = Oct 1997 | pmid = 9393982 | doi = 10.1038/sj.onc.1201394 | doi-access = free | citeseerx = 10.1.1.462.8435 }}
- {{cite journal | vauthors = Teigelkamp S, Mundt C, Achsel T, Will CL, Lührmann R | title = The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p | journal = RNA | volume = 3 | issue = 11 | pages = 1313–26 | date = Nov 1997 | pmid = 9409622 | pmc = 1369570 }}
- {{cite journal | vauthors = Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F | title = The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction | journal = The Journal of Biological Chemistry | volume = 273 | issue = 41 | pages = 26261–4 | date = Oct 1998 | pmid = 9756848 | doi = 10.1074/jbc.273.41.26261 | doi-access = free }}
- {{cite journal | vauthors = Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC | title = The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor | journal = RNA | volume = 4 | issue = 12 | pages = 1493–9 | date = Dec 1998 | pmid = 9848648 | pmc = 1369720 | doi = 10.1017/S1355838298981183 }}
- {{cite journal | vauthors = Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G | title = Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB | journal = Journal of Cellular Biochemistry | volume = 76 | issue = 4 | pages = 559–66 | date = Jan 2000 | pmid = 10653975 | doi = 10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U | s2cid = 25669908 }}
- {{cite journal | vauthors = Urban RJ, Bodenburg Y, Kurosky A, Wood TG, Gasic S | title = Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element | journal = Molecular Endocrinology | volume = 14 | issue = 6 | pages = 774–82 | date = Jun 2000 | pmid = 10847580 | doi = 10.1210/mend.14.6.0485 | doi-access = free }}
- {{cite journal | vauthors = Straub T, Knudsen BR, Boege F | title = PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices | journal = Biochemistry | volume = 39 | issue = 25 | pages = 7552–8 | date = Jun 2000 | pmid = 10858305 | doi = 10.1021/bi992898e }}
- {{cite journal | vauthors = Akhmedov AT, Lopez BS | title = Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion | journal = Nucleic Acids Research | volume = 28 | issue = 16 | pages = 3022–30 | date = Aug 2000 | pmid = 10931916 | pmc = 108454 | doi = 10.1093/nar/28.16.3022 }}
- {{cite journal | vauthors = de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W | title = Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors | journal = The EMBO Journal | volume = 19 | issue = 21 | pages = 5895–904 | date = Nov 2000 | pmid = 11060040 | pmc = 305781 | doi = 10.1093/emboj/19.21.5895 }}
- {{cite journal | vauthors = Dye BT, Patton JG | title = An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles | journal = Experimental Cell Research | volume = 263 | issue = 1 | pages = 131–44 | date = Feb 2001 | pmid = 11161712 | doi = 10.1006/excr.2000.5097 }}
- {{cite journal | vauthors = Mathur M, Tucker PW, Samuels HH | title = PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors | journal = Molecular and Cellular Biology | volume = 21 | issue = 7 | pages = 2298–311 | date = Apr 2001 | pmid = 11259580 | pmc = 86864 | doi = 10.1128/MCB.21.7.2298-2311.2001 }}
- {{cite journal | vauthors = Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J, Zipori D | title = Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions | journal = Molecular Biology of the Cell | volume = 12 | issue = 8 | pages = 2328–40 | date = Aug 2001 | pmid = 11514619 | pmc = 58597 | doi = 10.1091/mbc.12.8.2328 }}
- {{cite journal | vauthors = Zhang Z, Carmichael GG | title = The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs | journal = Cell | volume = 106 | issue = 4 | pages = 465–75 | date = Aug 2001 | pmid = 11525732 | doi = 10.1016/S0092-8674(01)00466-4 | s2cid = 18799711 | doi-access = free }}
- {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free }}
- {{cite journal | vauthors = Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR | title = Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription | journal = Endocrinology | volume = 143 | issue = 4 | pages = 1280–90 | date = Apr 2002 | pmid = 11897684 | doi = 10.1210/endo.143.4.8748 | doi-access = free }}
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