SFRS11
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.{{cite journal |author1=Chaudhary N |author2=McMahon C |author3=Blobel G | title = Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 18 | pages = 8189–93 |date=October 1991 | pmid = 1896467 | pmc = 52472 | doi =10.1073/pnas.88.18.8189 |bibcode=1991PNAS...88.8189C |doi-access=free }}{{cite web | title = Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9295}}
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.
Interactions
SFRS11 has been shown to interact with U2AF2.{{cite journal |last=Zhang |first=W J |author2=Wu J Y |date=October 1996 |title=Functional properties of p54, a novel SR protein active in constitutive and alternative splicing |journal=Mol. Cell. Biol. |volume=16 |issue=10 |pages=5400–8 |location = UNITED STATES| issn = 0270-7306| pmid = 8816452 |pmc=231539 |doi=10.1128/MCB.16.10.5400}}
References
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Further reading
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- {{cite journal |author1=Zhang WJ |author2=Wu JY |title=Functional properties of p54, a novel SR protein active in constitutive and alternative splicing |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5400–8 |year= 1996 |pmid= 8816452 |doi= 10.1128/MCB.16.10.5400| pmc=231539 }}
- {{cite journal |vauthors=Straub T, Grue P, Uhse A, etal |title=The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26261–4 |year= 1998 |pmid= 9756848 |doi=10.1074/jbc.273.41.26261 |doi-access=free }}
- {{cite journal |author1=Page-McCaw PS |author2=Amonlirdviman K |author3=Sharp PA |title=PUF60: a novel U2AF65-related splicing activity |journal=RNA |volume=5 |issue= 12 |pages= 1548–60 |year= 2000 |pmid= 10606266 |doi=10.1017/S1355838299991938 | pmc=1369877 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Sakashita E, Tatsumi S, Werner D, etal |title=Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1174–87 |year= 2004 |pmid= 14729963 |doi=10.1128/MCB.24.3.1174-1187.2004 | pmc=321435 }}
- {{cite journal |vauthors=Wu JY, Kar A, Kuo D, etal |title=SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy |journal=Mol. Cell. Biol. |volume=26 |issue= 18 |pages= 6739–47 |year= 2006 |pmid= 16943417 |doi= 10.1128/MCB.00739-06 | pmc=1592875 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
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