SGK3

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

In melanocytic cells SGK3 gene expression may be regulated by MITF.{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | s2cid = 24698373 | doi-access = free }}

SGK3 has been shown to interact with GSK3B.{{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | date = May 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }}

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• {{cite journal | vauthors = Lang F, Cohen P | title = Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms | journal = Sci. STKE | volume = 2001 | issue = 108 | pages = RE17 | year = 2002 | pmid = 11707620 | doi = 10.1126/stke.2001.108.re17 | s2cid = 25927734 }}
• {{cite journal | vauthors = Ali A, Hoeflich KP, Woodgett JR | title = Glycogen synthase kinase-3: properties, functions, and regulation | journal = Chem. Rev. | volume = 101 | issue = 8 | pages = 2527–40 | year = 2002 | pmid = 11749387 | doi = 10.1021/cr000110o }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB | title = Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 22 | pages = 11960–5 | year = 2000 | pmid = 11035810 | pmc = 17277 | doi = 10.1073/pnas.220413597 | bibcode = 2000PNAS...9711960F | doi-access = free }}
• {{cite journal | vauthors = Xu J, Liu D, Gill G, Songyang Z | title = Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides | journal = J. Cell Biol. | volume = 154 | issue = 4 | pages = 699–705 | year = 2001 | pmid = 11514587 | pmc = 2196448 | doi = 10.1083/jcb.200105089 }}
• {{cite journal | vauthors = Yun CC, Chen Y, Lang F | title = Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2 | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7676–83 | year = 2002 | pmid = 11751930 | doi = 10.1074/jbc.M107768200 | doi-access = free }}
• {{cite journal | vauthors = Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB | title = Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway | journal = Mol. Cell. Biol. | volume = 22 | issue = 7 | pages = 2099–110 | year = 2002 | pmid = 11884598 | pmc = 133668 | doi = 10.1128/MCB.22.7.2099-2110.2002 }}
• {{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | year = 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }}
• {{cite journal | vauthors = Brickley DR, Mikosz CA, Hagan CR, Conzen SD | title = Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1) | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43064–70 | year = 2003 | pmid = 12218062 | doi = 10.1074/jbc.M207604200 | doi-access = free }}
• {{cite journal | vauthors = Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F | title = K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK | journal = Pflügers Arch. | volume = 445 | issue = 1 | pages = 60–6 | year = 2003 | pmid = 12397388 | doi = 10.1007/s00424-002-0873-2 | s2cid = 21073737 }}
• {{cite journal | vauthors = Henke G, Setiawan I, Böhmer C, Lang F | title = Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms | journal = Kidney Blood Press. Res. | volume = 25 | issue = 6 | pages = 370–4 | year = 2003 | pmid = 12590200 | doi = 10.1159/000068699 | s2cid = 30241243 }}
• {{cite journal | vauthors = Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F | title = The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC | journal = Pflügers Arch. | volume = 445 | issue = 6 | pages = 693–6 | year = 2003 | pmid = 12632189 | doi = 10.1007/s00424-002-0993-8 | s2cid = 32511608 }}
• {{cite journal | vauthors = Embark HM, Böhmer C, Vallon V, Luft F, Lang F | title = Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms | journal = Pflügers Arch. | volume = 445 | issue = 5 | pages = 601–6 | year = 2003 | pmid = 12634932 | doi = 10.1007/s00424-002-0982-y | s2cid = 22981271 }}
• {{cite journal | vauthors = Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S | title = Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner | journal = J. Biol. Chem. | volume = 279 | issue = 6 | pages = 4794–801 | year = 2004 | pmid = 14604990 | doi = 10.1074/jbc.M309653200 | doi-access = free }}

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{{Serine/threonine-specific protein kinases}}

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Category:EC 2.7.11

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