Login
Login

SH2D1B

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.{{cite journal | vauthors = Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C | title = EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene | journal = Oncogene | volume = 13 | issue = 12 | pages = 2649–58 |date=Feb 1997 | pmid = 9000139 }}{{cite journal | vauthors = Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C | title = Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells | journal = EMBO J | volume = 20 | issue = 21 | pages = 5840–52 |date=Nov 2001 | pmid = 11689425 | pmc = 125701 | doi = 10.1093/emboj/20.21.5840 }}{{cite web | title = Entrez Gene: SH2D1B SH2 domain containing 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117157}}

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM]

Interactions

SH2D1B has been shown to interact with SLAMF1.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Morra M, Howie D, Grande MS, etal |title=X-linked lymphoproliferative disease: a progressive immunodeficiency |journal=Annu. Rev. Immunol. |volume=19 |pages= 657–82 |year= 2001 |pmid= 11244050 |doi= 10.1146/annurev.immunol.19.1.657 }}
  • {{cite journal | vauthors=Veillette A, Latour S |title=The SLAM family of immune-cell receptors |journal=Curr. Opin. Immunol. |volume=15 |issue= 3 |pages= 277–85 |year= 2004 |pmid= 12787752 |doi=10.1016/S0952-7915(03)00041-4 }}
  • {{cite journal | vauthors=Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD |title=CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2 |journal=Eur. J. Immunol. |volume=32 |issue= 6 |pages= 1640–9 |year= 2002 |pmid= 12115647 |doi= 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
  • {{cite journal | vauthors=Eissmann P, Watzl C |title=Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3170–7 |year= 2006 |pmid= 16920955 |doi= 10.4049/jimmunol.177.5.3170|doi-access=free }}

{{refend}}

{{gene-1-stub}}