SH3RF1

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.

SH3RF1 has been shown to interact with AKT2{{cite journal | vauthors = Figueroa C, Tarras S, Taylor J, Vojtek AB | title = Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47922–7 | date = Nov 2003 | pmid = 14504284 | doi = 10.1074/jbc.M307357200 | doi-access = free }} and MAP3K11.

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• {{cite journal | vauthors = Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK | title = Regulation of the Pro-apoptotic scaffolding protein POSH by Akt | journal = J. Biol. Chem. | volume = 282 | issue = 30 | pages = 21987–97 | year = 2007 | pmid = 17535800 | doi = 10.1074/jbc.M704321200 | doi-access = free }}
• {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
• {{cite journal | vauthors = Alroy I, Tuvia S, Greener T, Gordon D, Barr HM, Taglicht D, Mandil-Levin R, Ben-Avraham D, Konforty D, Nir A, Levius O, Bicoviski V, Dori M, Cohen S, Yaar L, Erez O, Propheta-Meiran O, Koskas M, Caspi-Bachar E, Alchanati I, Sela-Brown A, Moskowitz H, Tessmer U, Schubert U, Reiss Y | title = The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 5 | pages = 1478–83 | year = 2005 | pmid = 15659549 | pmc = 545085 | doi = 10.1073/pnas.0408717102 | bibcode = 2005PNAS..102.1478A | doi-access = free }}
• {{cite journal | vauthors = Figueroa C, Tarras S, Taylor J, Vojtek AB | title = Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47922–7 | year = 2003 | pmid = 14504284 | doi = 10.1074/jbc.M307357200 | doi-access = free }}
• {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
• {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 2 | pages = 143–50 | year = 2000 | pmid = 10819331 | doi = 10.1093/dnares/7.2.143 | doi-access = free }}

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