SHC2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.{{cite journal |author1=Kavanaugh WM |author2=Williams LT | title = An alternative to SH2 domains for binding tyrosine-phosphorylated proteins | journal = Science | volume = 266 | issue = 5192 | pages = 1862–5 |date=Jan 1995 | pmid = 7527937 | doi =10.1126/science.7527937 |bibcode=1994Sci...266.1862K }}{{cite journal |author1=Nakamura T |author2=Muraoka S |author3=Sanokawa R |author4=Mori N | title = N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling | journal = J Biol Chem | volume = 273 | issue = 12 | pages = 6960–7 |date=Apr 1998 | pmid = 9507002 | doi =10.1074/jbc.273.12.6960 | doi-access =free }}{{cite web | title = Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25759}}
Interactions
SHC2 has been shown to interact with Kinase insert domain receptor.{{cite journal |doi=10.1042/0264-6021:3470501 |last=Warner |first=A J |author2=Lopez-Dee J |author3=Knight E L |author4=Feramisco J R |author5=Prigent S A |date=Apr 2000 |title=The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells |journal=Biochem. J. |volume=347 |issue=Pt 2 |pages=501–9 |location = England| issn = 0264-6021| pmid = 10749680 |pmc=1220983 }}
References
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Further reading
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- {{cite journal |vauthors=Choy KW, Wang CC, Ogura A, etal |title=Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. |journal=Physiol. Genomics |volume=25 |issue= 1 |pages= 9–15 |year= 2007 |pmid= 16368877 |doi= 10.1152/physiolgenomics.00121.2005 }}
- {{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |author1=Liu HY |author2=Meakin SO |title=ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26046–56 |year= 2002 |pmid= 12006576 |doi= 10.1074/jbc.M111659200 |doi-access=free }}
- {{cite journal |vauthors=Warner AJ, Lopez-Dee J, Knight EL, etal |title=The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. |journal=Biochem. J. |volume=347 |issue= Pt 2 |pages= 501–9 |year= 2001 |pmid= 10749680 |doi= 10.1042/0264-6021:3470501| pmc=1220983 }}
- {{cite journal |vauthors=Pelicci G, Dente L, De Giuseppe A, etal |title=A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. |journal=Oncogene |volume=13 |issue= 3 |pages= 633–41 |year= 1996 |pmid= 8760305 }}
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