SHPRH
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.{{cite journal | vauthors = Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM | title = Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region | journal = Genomics | volume = 82 | issue = 2 | pages = 153–61 | date = August 2003 | pmid = 12837266 | doi = 10.1016/S0888-7543(03)00121-6 | url = https://zenodo.org/record/1260099 }}{{cite web | title = Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=257218}}
Function
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]
SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.{{cite journal |last1=Brühl |first1=J |last2=Trautwein |first2=J |last3=Schäfer |first3=A |last4=Linne |first4=U |last5=Bouazoune |first5=K |title=The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase. |journal=Epigenetics & Chromatin |date=21 August 2019 |volume=12 |issue=1 |pages=52 |doi=10.1186/s13072-019-0294-5 |pmid=31434570 |pmc=6702750 |doi-access=free }}
References
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Further reading
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- {{cite journal | vauthors = Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K | title = Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination | journal = The Journal of Cell Biology | volume = 175 | issue = 5 | pages = 703–8 | date = December 2006 | pmid = 17130289 | pmc = 2064669 | doi = 10.1083/jcb.200606145 }}
- {{cite journal | vauthors = Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L | title = Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 48 | pages = 18107–12 | date = November 2006 | pmid = 17108083 | pmc = 1838714 | doi = 10.1073/pnas.0608595103 | bibcode = 2006PNAS..10318107U | doi-access = free }}
- {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = August 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 | s2cid = 2371325 | url = http://faculty.washington.edu/scottjdw/pdfs/jin_curr_biol_2004_p1436.pdf }}
- {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | doi = | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
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