SIN3A

{{Short description|Protein-coding gene in the species Homo sapiens}}

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.{{cite journal | vauthors = Yu F, Thiesen J, Strätling WH | title = Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2 | journal = Nucleic Acids Research | volume = 28 | issue = 10 | pages = 2201–6 | date = May 2000 | pmid = 10773092 | pmc = 105362 | doi = 10.1093/nar/28.10.2201 }}{{cite journal | vauthors = Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA | title = A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3 | journal = Genomics | volume = 26 | issue = 2 | pages = 403–6 | date = March 1995 | pmid = 7601471 | doi = 10.1016/0888-7543(95)80229-F }}

Function

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.{{cite web | title = Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25942}}

Interactions

SIN3A has been shown to interact with:

CABIN1{{cite journal | vauthors = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | date = July 2000 | pmid = 10933397 | doi = 10.1016/S1074-7613(00)00010-8 | doi-access = free }}
HBP1,
HDAC1,{{cite journal | vauthors = Zhang Y, Dufau ML | title = Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 85 | issue = 2–5 | pages = 401–14 | date = June 2003 | pmid = 12943729 | doi = 10.1016/S0960-0760(03)00230-9 | s2cid = 28512341 | url = https://zenodo.org/record/1260176 }}{{cite journal | vauthors = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42560–8 | date = October 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200 | doi-access = free }}{{cite journal | vauthors = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 651–7 | date = February 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854 }}{{cite journal | vauthors = Grozinger CM, Hassig CA, Schreiber SL | title = Three proteins define a class of human histone deacetylases related to yeast Hda1p | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 9 | pages = 4868–73 | date = April 1999 | pmid = 10220385 | pmc = 21783 | doi = 10.1073/pnas.96.9.4868 | bibcode = 1999PNAS...96.4868G | doi-access = free }}{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Molecular Cell | volume = 9 | issue = 3 | pages = 611–23 | date = March 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9 | doi-access = free }}{{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 4 | pages = 1454–8 | date = February 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 | bibcode = 2001PNAS...98.1454Y | doi-access = free }}{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = August 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}{{cite journal | vauthors = Zhang Y, Dufau ML | title = Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 36 | pages = 33431–8 | date = September 2002 | pmid = 12091390 | doi = 10.1074/jbc.M204417200 | doi-access = free }}{{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | date = October 1998 | pmid = 9804427 | doi = 10.1038/27699 | bibcode = 1998Natur.395..917T | s2cid = 4355885 }}{{cite journal | vauthors = Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL | title = A role for histone deacetylase activity in HDAC1-mediated transcriptional repression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3519–24 | date = March 1998 | pmid = 9520398 | pmc = 19868 | doi = 10.1073/pnas.95.7.3519 | bibcode = 1998PNAS...95.3519H | doi-access = free }}{{cite journal | vauthors = Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T | title = SATB1 targets chromatin remodelling to regulate genes over long distances | journal = Nature | volume = 419 | issue = 6907 | pages = 641–5 | date = October 2002 | pmid = 12374985 | doi = 10.1038/nature01084 | bibcode = 2002Natur.419..641Y | s2cid = 25822700 | url = https://digital.library.unt.edu/ark:/67531/metadc733622/ }}
HDAC9,{{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23143–9 | date = June 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 | doi-access = free }}{{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 | doi-access = free }}
Histone deacetylase 2,{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = February 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 | doi-access = free}}{{cite journal | vauthors = Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN | title = Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression | journal = Cell | volume = 89 | issue = 3 | pages = 349–56 | date = May 1997 | pmid = 9150134 | doi = 10.1016/S0092-8674(00)80215-9 | s2cid = 13490886 | doi-access = free }}
Host cell factor C1,{{cite journal | vauthors = Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML | title = Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | journal = Molecular and Cellular Biology | volume = 24 | issue = 13 | pages = 5639–49 | date = July 2004 | pmid = 15199122 | pmc = 480881 | doi = 10.1128/MCB.24.13.5639-5649.2004 }}{{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = April 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
IKZF1,{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = June 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = August 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 | doi-access = free }}
ING1,
KLF11,{{cite journal | vauthors = Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R | title = A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A | journal = Molecular and Cellular Biology | volume = 21 | issue = 15 | pages = 5041–9 | date = August 2001 | pmid = 11438660 | pmc = 87230 | doi = 10.1128/MCB.21.15.5041-5049.2001 }}{{cite journal | vauthors = Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R | title = Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor | journal = The EMBO Journal | volume = 21 | issue = 10 | pages = 2451–60 | date = May 2002 | pmid = 12006497 | pmc = 126002 | doi = 10.1093/emboj/21.10.2451 }}
MNT,{{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | journal = The EMBO Journal | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | pmid = 9184233 | pmc = 1169897 | doi = 10.1093/emboj/16.10.2892 }}
MXD1,{{cite journal | vauthors = Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I | title = HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations | journal = Nature Structural & Molecular Biology | volume = 11 | issue = 8 | pages = 738–46 | date = August 2004 | pmid = 15235594 | doi = 10.1038/nsmb798 | s2cid = 44324333 }}{{cite journal | vauthors = Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I | title = Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex | journal = Cell | volume = 103 | issue = 4 | pages = 655–65 | date = November 2000 | pmid = 11106735 | doi = 10.1016/S0092-8674(00)00168-9 | s2cid = 17476603 | doi-access = free }}{{cite journal | vauthors = Ayer DE, Lawrence QA, Eisenman RN | title = Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 | journal = Cell | volume = 80 | issue = 5 | pages = 767–76 | date = March 1995 | pmid = 7889570 | doi = 10.1016/0092-8674(95)90355-0 | s2cid = 8749951 | doi-access = free }}
Methyl-CpG-binding domain protein 2,{{cite journal | vauthors = Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R | title = The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A | journal = The Journal of Biological Chemistry | volume = 275 | issue = 45 | pages = 34963–7 | date = November 2000 | pmid = 10950960 | doi = 10.1074/jbc.M005929200 | doi-access = free }}
Nuclear receptor co-repressor 2,{{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | journal = Genes & Development | volume = 14 | issue = 1 | pages = 45–54 | date = January 2000 | doi = 10.1101/gad.14.1.45 | pmid = 10640275 | pmc = 316335 }}{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}
OGT,{{cite journal | vauthors = Yang X, Zhang F, Kudlow JE | title = Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression | journal = Cell | volume = 110 | issue = 1 | pages = 69–80 | date = July 2002 | pmid = 12150998 | doi = 10.1016/S0092-8674(02)00810-3 | s2cid = 2380973 | doi-access = free }}
PHF12,
Promyelocytic leukemia protein,{{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Molecular Cell | volume = 7 | issue = 6 | pages = 1233–43 | date = June 2001 | pmid = 11430826 | doi = 10.1016/S1097-2765(01)00257-X | doi-access = free }}
RBBP4,{{cite journal | vauthors = Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE | title = Histone deacetylase activity is required for full transcriptional repression by mSin3A | journal = Cell | volume = 89 | issue = 3 | pages = 341–7 | date = May 1997 | pmid = 9150133 | doi = 10.1016/S0092-8674(00)80214-7 | s2cid = 14233219 | doi-access = free }}
RBBP7,{{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = February 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002 }}{{cite journal | vauthors = Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D | title = SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex | journal = Molecular Cell | volume = 1 | issue = 7 | pages = 1021–31 | date = June 1998 | pmid = 9651585 | doi = 10.1016/S1097-2765(00)80102-1 | doi-access = free }}
SAP130,{{cite journal | vauthors = Fleischer TC, Yun UJ, Ayer DE | title = Identification and characterization of three new components of the mSin3A corepressor complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 10 | pages = 3456–67 | date = May 2003 | pmid = 12724404 | pmc = 164750 | doi = 10.1128/MCB.23.10.3456-3467.2003 }}
SAP30,{{cite journal | vauthors = Yochum GS, Ayer DE | title = Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 13 | pages = 4110–8 | date = July 2001 | pmid = 11390640 | pmc = 87072 | doi = 10.1128/MCB.21.13.4110-4118.2001 }}{{cite journal | vauthors = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors | journal = Molecular Cell | volume = 2 | issue = 1 | pages = 33–42 | date = July 1998 | pmid = 9702189 | doi = 10.1016/S1097-2765(00)80111-2 | doi-access = free }}
SMARCA2,{{cite journal | vauthors = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | journal = Genes & Development | volume = 15 | issue = 5 | pages = 603–18 | date = March 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801 }}
SMARCA4,
SMARCC1,
SUDS3,{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = April 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}
TAL1,{{cite journal | vauthors = Huang S, Brandt SJ | title = mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor | journal = Molecular and Cellular Biology | volume = 20 | issue = 6 | pages = 2248–59 | date = March 2000 | pmid = 10688671 | pmc = 110841 | doi = 10.1128/MCB.20.6.2248-2259.2000 }} and
Zinc finger and BTB domain-containing protein 16.{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 | s2cid = 655636 | doi-access = }}{{cite journal | vauthors = Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP | title = The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor | journal = Blood | volume = 98 | issue = 12 | pages = 3290–300 | date = December 2001 | pmid = 11719366 | doi = 10.1182/blood.V98.12.3290 | doi-access = free }}{{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 | doi-access = free }}

References

External links

{{MeshName|SIN3A+protein,+human}}
{{FactorBook|Sin3Ak-20}}

Category:Gene expression

Category:Transcription coregulators

SIN3A

Function

Interactions

See also

References

Further reading

External links