SIPA1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.{{cite journal | vauthors = Wada Y, Kubota H, Maeda M, Taniwaki M, Hattori M, Imamura S, Iwai K, Minato N | title = Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human | journal = Genomics | volume = 39 | issue = 1 | pages = 66–73 |date=Mar 1997 | pmid = 9027487 | doi = 10.1006/geno.1996.4464 }}{{cite web | title = Entrez Gene: SIPA1 signal-induced proliferation-associated gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6494}}
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
References
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Further reading
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- {{cite journal | author=Minato N |title=[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene] |journal=Hum. Cell |volume=9 |issue= 1 |pages= 11–6 |year= 1997 |pmid= 9183624 }}
- {{cite journal |vauthors=Hattori M, Tsukamoto N, Nur-e-Kamal MS, etal |title=Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 552–60 |year= 1995 |pmid= 7799964 |doi= 10.1128/mcb.15.1.552| pmc=232010 }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Kurachi H, Wada Y, Tsukamoto N, etal |title=Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 28081–8 |year= 1997 |pmid= 9346962 |doi=10.1074/jbc.272.44.28081 |s2cid=26338837 |doi-access=free }}
- {{cite journal |vauthors=Ebrahimi S, Wang E, Udar N, etal |title=Genomic organization and cloning of the human homologue of murine Sipa-1 |journal=Gene |volume=214 |issue= 1–2 |pages= 215–21 |year= 1998 |pmid= 9651531 |doi=10.1016/S0378-1119(98)00212-1 }}
- {{cite journal |vauthors=Tsukamoto N, Hattori M, Yang H, etal |title=Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18463–9 |year= 1999 |pmid= 10373454 |doi=10.1074/jbc.274.26.18463 |s2cid=46045210 |doi-access=free }}
- {{cite journal | vauthors=Hoecker U, Quail PH |title=The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis |journal=J. Biol. Chem. |volume=276 |issue= 41 |pages= 38173–8 |year= 2001 |pmid= 11461903 |doi= 10.1074/jbc.M103140200 |doi-access= free }}
- {{cite journal |vauthors=Roy BC, Kohu K, Matsuura K, etal |title=SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus |journal=Genes Cells |volume=7 |issue= 6 |pages= 607–17 |year= 2003 |pmid= 12059963 |doi=10.1046/j.1365-2443.2002.00546.x |s2cid=42090467 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Farina A, Hattori M, Qin J, etal |title=Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9059–69 |year= 2004 |pmid= 15456879 |doi= 10.1128/MCB.24.20.9059-9069.2004 | pmc=517877 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Crawford NP, Ziogas A, Peel DJ, etal |title=Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer |journal=Breast Cancer Res. |volume=8 |issue= 2 |pages= R16 |year= 2006 |pmid= 16563182 |doi= 10.1186/bcr1389 | pmc=1483843 |doi-access=free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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