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SIRPB1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.{{cite journal |author1=Kharitonenkov A |author2=Chen Z |author3=Sures I |author4=Wang H |author5=Schilling J |author6=Ullrich A | title = A family of proteins that inhibit signalling through tyrosine kinase receptors | journal = Nature | volume = 386 | issue = 6621 | pages = 181–6 |date=April 1997 | pmid = 9062191 | doi = 10.1038/386181a0 |bibcode=1997Natur.386..181K |s2cid=4259314 }}{{cite journal |author1=van den Berg TK |author2=van Beek EM |author3=Buhring HJ |author4=Colonna M |author5=Hamaguchi M |author6=Howard CJ |author7=Kasuga M |author8=Liu Y |author9=Matozaki T |author10=Neel BG |author11=Parkos CA |author12=Sano S |author13=Vignery A |author14=Vivier E |author15=Wright M |author16=Zawatzky R |author17=Barclay AN | title = A nomenclature for signal regulatory protein family members | journal = J Immunol | volume = 175 | issue = 12 | pages = 7788–9 |date=December 2005 | pmid = 16339511 | doi = 10.4049/jimmunol.175.12.7788|doi-access= |s2cid=41479985 }} SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.{{cite web | title = Entrez Gene: SIRPB1 signal-regulatory protein beta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10326}}

Interactions

SIRPB1 has been shown to interact with TYROBP.{{cite journal |last=Dietrich |first=J |author2=Cella M |author3=Seiffert M |author4=Bühring H J |author5=Colonna M |date=January 2000 |title=Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells |journal=J. Immunol. |volume=164 |issue=1 |pages=9–12 |location = UNITED STATES| issn = 0022-1767| pmid = 10604985 | doi=10.4049/jimmunol.164.1.9|doi-access=free }}{{cite journal |last=Tomasello |first=E |author2=Cant C |author3=Bühring H J |author4=Vély F |author5=André P |author6=Seiffert M |author7=Ullrich A |author8=Vivier E |date=August 2000 |title=Association of signal-regulatory proteins beta with KARAP/DAP-12 |journal=Eur. J. Immunol. |volume=30 |issue=8 |pages=2147–56 |location = GERMANY| issn = 0014-2980| pmid = 10940905 |doi=10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1 |doi-access= |s2cid=84258013 }}

References

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Further reading

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  • {{cite journal |vauthors=Dietrich J, Cella M, Seiffert M, etal |title=Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. |journal=J. Immunol. |volume=164 |issue= 1 |pages= 9–12 |year= 2000 |pmid= 10604985 |doi= 10.4049/jimmunol.164.1.9|doi-access=free }}
  • {{cite journal |vauthors=Tomasello E, Cant C, Bühring HJ, etal |title=Association of signal-regulatory proteins beta with KARAP/DAP-12. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2147–56 |year= 2000 |pmid= 10940905 |doi=10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1 |doi-access= |s2cid=84258013 }}
  • {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access=free }}
  • {{cite journal |author1=Cannon JP |author2=Haire RN |author3=Litman GW |title=Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1200–7 |year= 2002 |pmid= 12415263 |doi= 10.1038/ni849 |s2cid=19367972 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Liu Y, Soto I, Tong Q, etal |title=SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36132–40 |year= 2006 |pmid= 16081415 |doi= 10.1074/jbc.M506419200 |doi-access= free }}
  • {{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
  • {{cite journal | vauthors = Laplana M, Royo JL, Aluja A, López R, Heine-Sunyer H, Fibla J | title = SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality | journal = Genes, Brain and Behavior | volume = 13 | issue = 7 | pages = 653–62 | date = September 2014 | pmid = 25039969 | doi = 10.1111/gbb.12154 | doi-access = free | hdl = 10486/667487 | hdl-access = free }}

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External links

  • {{UCSC genome browser|SIRPB1}}
  • {{UCSC gene details|SIRPB1}}

{{PDB Gallery|geneid=10326}}

{{NLM content}}

{{Clusters of differentiation}}

Category:Clusters of differentiation