SKAP2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.{{cite journal | vauthors = Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T | title = RA70 is a src kinase-associated protein expressed ubiquitously | journal = Biochemical and Biophysical Research Communications | volume = 252 | issue = 3 | pages = 738–42 | date = November 1998 | pmid = 9837776 | doi = 10.1006/bbrc.1998.9637 }}{{cite journal | vauthors = Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B | title = SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55 | journal = FEBS Letters | volume = 435 | issue = 1 | pages = 55–60 | date = September 1998 | pmid = 9755858 | doi = 10.1016/S0014-5793(98)01040-0 | s2cid = 37288744 | doi-access = free }}{{cite web | title = Entrez Gene: SKAP2 src kinase associated phosphoprotein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8935}}
Function
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.{{cite journal | vauthors = Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD | title = Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement | language = en | journal = Journal of Cell Science | volume = 125 | issue = Pt 22 | pages = 5535–45 | date = November 2012 | pmid = 22976304 | doi = 10.1242/jcs.111260 | pmc=3561861}}
References
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Further reading
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- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE | title = FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8779–84 | date = July 1998 | pmid = 9671755 | pmc = 21153 | doi = 10.1073/pnas.95.15.8779 | bibcode = 1998PNAS...95.8779L | doi-access = free }}
- {{cite journal | vauthors = Wang X, Stollar BD | title = Immunoglobulin VH gene expression in human aging | journal = Clinical Immunology | volume = 93 | issue = 2 | pages = 132–42 | date = November 1999 | pmid = 10527689 | doi = 10.1006/clim.1999.4781 }}
- {{cite journal | vauthors = Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP | title = Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin | journal = The Journal of Biological Chemistry | volume = 275 | issue = 43 | pages = 33427–34 | date = October 2000 | pmid = 10942756 | doi = 10.1074/jbc.M001439200 | doi-access = free }}
- {{cite journal | vauthors = Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG | title = Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest | journal = Experimental Hematology | volume = 28 | issue = 11 | pages = 1250–9 | date = November 2000 | pmid = 11063873 | doi = 10.1016/S0301-472X(00)00537-3 | url = https://zenodo.org/record/1259993 | doi-access = free }}
- {{cite journal | vauthors = Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G | title = PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 25 | pages = 22375–81 | date = June 2001 | pmid = 11301322 | doi = 10.1074/jbc.M011683200 | doi-access = free }}
- {{cite journal | vauthors = Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B | title = The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain | journal = The Journal of Experimental Medicine | volume = 193 | issue = 11 | pages = 1269–84 | date = June 2001 | pmid = 11390434 | pmc = 2193385 | doi = 10.1084/jem.193.11.1269 }}
- {{cite journal | vauthors = Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, Avraham S, Yasuda M, Matsumoto M | title = Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42225–33 | date = October 2003 | pmid = 12893833 | doi = 10.1074/jbc.M213217200 | doi-access = free }}
- {{cite journal | vauthors = Park SY, Avraham HK, Avraham S | title = RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33315–22 | date = August 2004 | pmid = 15166227 | doi = 10.1074/jbc.M313527200 | doi-access = free }}
- {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }}
- {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
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