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SLA2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.{{cite journal | vauthors = Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J | title = Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling | journal = J Exp Med | volume = 194 | issue = 9 | pages = 1263–76 | date = Nov 2001 | pmid = 11696592 | pmc = 2195979 | doi = 10.1084/jem.194.9.1263 | citeseerx = 10.1.1.283.1429 }}{{cite web | title = Entrez Gene: SLA2 Src-like-adaptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84174}}

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

SLA2 has been shown to interact with Cbl gene.{{cite journal | vauthors = Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M | title = A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19131–8 | date = May 2002 | pmid = 11891219 | doi = 10.1074/jbc.M110318200 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Loreto MP, McGlade CJ | title = Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. | journal = Oncogene | volume = 22 | issue = 2 | pages = 266–73 | year = 2003 | pmid = 12527895 | doi = 10.1038/sj.onc.1206114 | doi-access = free }}
  • {{cite journal | vauthors = Loreto MP, Berry DM, McGlade CJ | title = Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. | journal = Mol. Cell. Biol. | volume = 22 | issue = 12 | pages = 4241–55 | year = 2002 | pmid = 12024036 | pmc = 133880 | doi = 10.1128/MCB.22.12.4241-4255.2002 }}
  • {{cite journal | vauthors = Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M | title = A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19131–8 | year = 2002 | pmid = 11891219 | doi = 10.1074/jbc.M110318200 | doi-access = free }}

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