SLC22A7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.{{cite journal | vauthors = Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H | title = Identification of multispecific organic anion transporter 2 expressed predominantly in the liver | journal = FEBS Lett | volume = 429 | issue = 2 | pages = 179–82 | date = Jul 1998 | pmid = 9650585 | doi =10.1016/S0014-5793(98)00585-7 | s2cid = 30015233 | doi-access = free }}{{cite journal | vauthors = Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM | title = Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids | journal = Cytogenet Cell Genet | volume = 88 | issue = 1–2 | pages = 76–7 | date = Jun 2000 | pmid = 10773670 | doi =10.1159/000015489 | s2cid = 8702529 }}{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864}}
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.
Interactive pathway map
{{FluoropyrimidineActivity WP1601|highlight=SLC22A7}}
See also
- {{MeshName|SLC22A7+protein,+human}}
References
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Further reading
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- {{cite journal |vauthors=Cropp CD, Komori T, Shima JE, etal |title=Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP |journal=Mol. Pharmacol. |volume=73 |issue= 4 |pages= 1151–8 |year= 2008 |pmid= 18216183 |doi= 10.1124/mol.107.043117 | pmc=2698938 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Enomoto A, Takeda M, Shimoda M, etal |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797–802 |year= 2002 |pmid= 12023506 |doi=10.1124/jpet.301.3.797 }}
- {{cite journal |vauthors=Kimura H, Takeda M, Narikawa S, etal |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293–8 |year= 2002 |pmid= 11907186 |doi=10.1124/jpet.301.1.293 |s2cid=7739298 }}
- {{cite journal |vauthors=Babu E, Takeda M, Narikawa S, etal |title=Human organic anion transporters mediate the transport of tetracycline |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=10.1254/jjp.88.69 |doi-access=free }}
- {{cite journal | vauthors=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417–22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
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{{NLM content}}
{{Membrane transport proteins}}
Category:Solute carrier family
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