SLC23A2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.{{cite journal | vauthors = Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ | title = Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters | journal = Biochim Biophys Acta | volume = 1442 | issue = 2–3 | pages = 353–60 |date=Dec 1998 | pmid = 9804989 | doi = 10.1016/S0167-4781(98)00151-1}}{{cite journal | vauthors = Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA | title = A family of mammalian Na+-dependent L-ascorbic acid transporters | journal = Nature | volume = 399 | issue = 6731 | pages = 70–5 |date=Jun 1999 | pmid = 10331392 | doi = 10.1038/19986 | bibcode = 1999Natur.399...70T | s2cid = 4425479 }}{{cite web | title = Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962}}
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.
See also
References
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Further reading
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- {{cite journal | vauthors=Liang WJ, Johnson D, Jarvis SM |title=Vitamin C transport systems of mammalian cells. |journal=Mol. Membr. Biol. |volume=18 |issue= 1 |pages= 87–95 |year= 2001 |pmid= 11396616 |doi=10.1080/09687680110033774 |s2cid=22478598 |doi-access=free }}
- {{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free }}
- {{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 |doi-access=free }}
- {{cite journal | vauthors=Hogue DL, Ling V |title=A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. |journal=Genomics |volume=59 |issue= 1 |pages= 18–23 |year= 1999 |pmid= 10395795 |doi= 10.1006/geno.1999.5847 }}
- {{cite journal |vauthors=Rajan DP, Huang W, Dutta B, etal |title=Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 3 |pages= 762–8 |year= 1999 |pmid= 10471399 |doi= 10.1006/bbrc.1999.1272 }}
- {{cite journal |vauthors=Daruwala R, Song J, Koh WS, etal |title=Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. |journal=FEBS Lett. |volume=460 |issue= 3 |pages= 480–4 |year= 1999 |pmid= 10556521 |doi=10.1016/S0014-5793(99)01393-9 |s2cid=37936975 |doi-access=free }}
- {{cite journal |vauthors=Breton S, Wiederhold T, Marshansky V, etal |title=The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18219–24 |year= 2000 |pmid= 10748165 |doi= 10.1074/jbc.M909857199 |doi-access= free }}
- {{cite journal |vauthors=Holliday LS, Lu M, Lee BS, etal |title=The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32331–7 |year= 2000 |pmid= 10915794 |doi= 10.1074/jbc.M004795200 |doi-access= free }}
- {{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access= free }}
- {{cite journal | author=Hediger MA |title=New view at C. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 445–6 |year= 2002 |pmid= 11984580 |doi= 10.1038/nm0502-445 |s2cid=787845 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Fischer H, Schwarzer C, Illek B |title=Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3691–6 |year= 2004 |pmid= 14993613 |doi= 10.1073/pnas.0308393100 | pmc=373524 |bibcode=2004PNAS..101.3691F |doi-access=free }}
- {{cite journal | vauthors=Lutsenko EA, Carcamo JM, Golde DW |title=A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3150–6 |year= 2004 |pmid= 15060139 |doi=10.1128/MCB.24.8.3150-3156.2004 | pmc=381605 }}
- {{cite journal |vauthors=Seno T, Inoue N, Matsui K, etal |title=Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. |journal=J. Vasc. Res. |volume=41 |issue= 4 |pages= 345–51 |year= 2004 |pmid= 15340249 |doi= 10.1159/000080525 |s2cid=20754421 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal | vauthors=McNulty AL, Vail TP, Kraus VB |title=Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. |journal=Biochim. Biophys. Acta |volume=1712 |issue= 2 |pages= 212–21 |year= 2005 |pmid= 15921655 |doi= 10.1016/j.bbamem.2005.04.009 |doi-access= }}
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{{NLM content}}
{{Membrane transport proteins}}
Category:Solute carrier family
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