Login
Login

SLIT2

{{cs1 config|name-list-style=vanc}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.{{cite journal |author1=Itoh A |author2=Miyabayashi T |author3=Ohno M |author4=Sakano S | title = Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system | journal = Brain Res Mol Brain Res | volume = 62 | issue = 2 | pages = 175–86 |date=February 1999 | pmid = 9813312 | doi =10.1016/S0169-328X(98)00224-1 }}{{cite book | author = Chedotal A | chapter = Slits and Their Receptors | title = Axon Growth and Guidance | series = Advances in Experimental Medicine and Biology | volume = 621 | pages = 65–80 |date=February 2008 | pmid = 18269211 | doi = 10.1007/978-0-387-76715-4_5 | isbn = 978-0-387-76714-7 }}{{cite web | title = Entrez Gene: SLIT2 slit homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9353}}

Interactions

SLIT2 has been shown to interact with Glypican 1.{{cite journal |last=Ronca |first=F |author2=Andersen J S |author3=Paech V |author4=Margolis R U |date=August 2001 |title=Characterization of Slit protein interactions with glypican-1 |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29141–7 |location = United States| issn = 0021-9258| pmid = 11375980 |doi = 10.1074/jbc.M100240200 |doi-access=free }}

References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal |author1=Wong K |author2=Park HT |author3=Wu JY |author4=Rao Y |title=Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 5 |pages= 583–91 |year= 2003 |pmid= 12200164 |doi=10.1016/S0959-437X(02)00343-X }}
  • {{cite journal |author1=Zhao XC |author2=Zhang LM |author3=Li Q |author4=Tong DY |author5=Fan LC |author6=An P |author7=Wu XY |author8=Chen WM |author9=Zhao P |author10=Wang J. |title=Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1. |journal=Brain Res. |volume=1537 |pages= 283–9 |year= 2013 |pmid= 23994690 |doi=10.1016/j.brainres.2013.08.036 |pmc=3820100}}
  • {{cite journal |vauthors=Wang KH, Brose K, Arnott D, etal |title=Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. |journal=Cell |volume=96 |issue= 6 |pages= 771–84 |year= 1999 |pmid= 10102266 |doi=10.1016/S0092-8674(00)80588-7 |s2cid=16810644 |doi-access=free }}
  • {{cite journal |vauthors=Brose K, Bland KS, Wang KH, etal |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795–806 |year= 1999 |pmid= 10102268 |doi=10.1016/S0092-8674(00)80590-5 |s2cid=16301178 |doi-access=free }}
  • {{cite journal |vauthors=Li HS, Chen JH, Wu W, etal |title=Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. |journal=Cell |volume=96 |issue= 6 |pages= 807–18 |year= 1999 |pmid= 10102269 |doi=10.1016/S0092-8674(00)80591-7 |doi-access=free }}
  • {{cite journal |vauthors=Nguyen Ba-Charvet KT, Brose K, Marillat V, etal |title=Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. |journal=Neuron |volume=22 |issue= 3 |pages= 463–73 |year= 1999 |pmid= 10197527 |doi=10.1016/S0896-6273(00)80702-3 |s2cid=18663762 |doi-access=free }}
  • {{cite journal |vauthors=Holmes GP, Negus K, Burridge L, etal |title=Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. |journal=Mech. Dev. |volume=79 |issue= 1–2 |pages= 57–72 |year= 1999 |pmid= 10349621 |doi=10.1016/S0925-4773(98)00174-9 |s2cid=6057216 |doi-access=free }}
  • {{cite journal |vauthors=Liang Y, Annan RS, Carr SA, etal |title=Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17885–92 |year= 1999 |pmid= 10364234 |doi=10.1074/jbc.274.25.17885 |doi-access=free }}
  • {{cite journal |vauthors=Wu W, Wong K, Chen J, etal |title=Directional guidance of neuronal migration in the olfactory system by the protein Slit. |journal=Nature |volume=400 |issue= 6742 |pages= 331–6 |year= 1999 |pmid= 10432110 |doi= 10.1038/22477 | pmc=2041931 |bibcode=1999Natur.400..331W }}
  • {{cite journal |vauthors=Georgas K, Burridge L, Smith K, etal |title=Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3–4 |pages= 246–7 |year= 2000 |pmid= 10575218 |doi=10.1159/000015351 |s2cid=6028258 }}
  • {{cite journal |author1=Niclou SP |author2=Jia L |author3=Raper JA |title=Slit2 is a repellent for retinal ganglion cell axons. |journal=J. Neurosci. |volume=20 |issue= 13 |pages= 4962–74 |year= 2000 |pmid= 10864954 |doi= 10.1523/JNEUROSCI.20-13-04962.2000|pmc=6772294 }}
  • {{cite journal |author1=Zou Y |author2=Stoeckli E |author3=Chen H |author4=Tessier-Lavigne M |title=Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. |journal=Cell |volume=102 |issue=3 |pages=363–75 |year=2000 |pmid=10975526 |doi=10.1016/S0092-8674(00)00041-6 |s2cid=14174593 |url=https://www.zora.uzh.ch/id/eprint/248/1/Zou_00.pdf |access-date=2020-09-11 |archive-date=2018-11-01 |archive-url=https://web.archive.org/web/20181101080448/https://www.zora.uzh.ch/id/eprint/248/1/Zou_00.pdf |url-status=dead }}
  • {{cite journal |vauthors=Chen JH, Wen L, Dupuis S, etal |title=The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. |journal=J. Neurosci. |volume=21 |issue= 5 |pages= 1548–56 |year= 2001 |pmid= 11222645 |doi= 10.1523/JNEUROSCI.21-05-01548.2001|pmc=6762944 |doi-access=free }}
  • {{cite journal |vauthors=Wu JY, Feng L, Park HT, etal |title=The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. |journal=Nature |volume=410 |issue= 6831 |pages= 948–52 |year= 2001 |pmid= 11309622 |doi= 10.1038/35073616 | pmc=2072862 |bibcode=2001Natur.410..948W }}
  • {{cite journal |author1=Ronca F |author2=Andersen JS |author3=Paech V |author4=Margolis RU |title=Characterization of Slit protein interactions with glypican-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29141–7 |year= 2001 |pmid= 11375980 |doi= 10.1074/jbc.M100240200 |doi-access=free }}
  • {{cite journal |vauthors=Nguyen Ba-Charvet KT, Brose K, Ma L, etal |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11404413 |doi= 10.1523/JNEUROSCI.21-12-04281.2001|pmc=6762758 |doi-access=free }}
  • {{cite journal |vauthors=Little M, Rumballe B, Georgas K, etal |title=Conserved modularity and potential for alternate splicing in mouse and human Slit genes. |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 385–91 |year= 2003 |pmid= 12141424 }}
  • {{cite journal |vauthors=Dallol A, Da Silva NF, Viacava P, etal |title=SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5874–80 |year= 2002 |pmid= 12384551 }}

{{Refend}}

Category:Slit proteins

{{Gene-4-stub}}