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SLITRK2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.{{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 8 | issue = 2 | pages = 85–95 | date = April 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 | doi-access = free }}{{cite journal | vauthors = Aruga J, Yokota N, Mikoshiba K | title = Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue | journal = Gene | volume = 315 | pages = 87–94 | date = October 2003 | pmid = 14557068 | doi = 10.1016/S0378-1119(03)00715-7 }}{{cite web | title = Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84631}}

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.

References

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Further reading

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  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}

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