SMAC

• Second mitochondria-derived activator of caspases or Diablo homolog, a component of the apoptosis pathway
• Sequential Multiple Analysis - Computer or comprehensive metabolic panel, a panel of clinical chemistry lab tests
• Supramolecular activation cluster, the structure comprising the immunological synapse

• Sabang Merauke Raya Air Charter, an Indonesian airline
• Sarah McCreanor, known professionally as Smac
• Sid Meier's Alpha Centauri, a computer game
• Social Mobile Analytics Cloud, also called the third platform
• Southern Maryland Athletic Conference
• Southwestern Michigan Athletic Conference
• Stone Mountain Arts Center, an arts center in Brownville, Maine, United States, North America
• Supreme Macedonian-Adrianople Committee

• FBi SMAC Awards, Awards given by Sydney radio station FBi
• Smack (disambiguation)

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