SMARCD3

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein.

Multiple alternatively spliced transcript variants have been found for this gene. Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.{{cite journal | vauthors = Puri PL, Mercola M | title = BAF60 A, B, and Cs of muscle determination and renewal | journal = Genes & Development | volume = 26 | issue = 24 | pages = 2673–2683 | date = December 2012 | pmid = 23222103 | pmc = 3533072 | doi = 10.1101/gad.207415.112 }}

SMARCD3 together with TBX15 triggers development glycolytic fast-twitch muscles by the activation of the Akt/PKB signaling pathway.{{cite journal | vauthors = Omairi S, Matsakas A, Degens H, Kretz O, Hansson KA, Solbrå AV, Bruusgaard JC, Joch B, Sartori R, Giallourou N, Mitchell R, Collins-Hooper H, Foster K, Pasternack A, Ritvos O, Sandri M, Narkar V, Swann JR, Huber TB, Patel K | title = Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres | journal = eLife | volume = 5 | pages = e16940 | date = August 2016 | pmid = 27494364 | pmc = 4975572 | doi = 10.7554/eLife.16940 | veditors = Cossu G | doi-access = free }}

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• {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–5382 | date = October 1996 | pmid = 8895581 | pmc = 452280 | doi = 10.1002/j.1460-2075.1996.tb00921.x }}
• {{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1460–1469 | date = February 1999 | pmid = 9891079 | pmc = 116074 | doi = 10.1128/mcb.19.2.1460 }}
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• {{cite journal | vauthors = Nagaraja GM, Kandpal RP | title = Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins | journal = Biochemical and Biophysical Research Communications | volume = 313 | issue = 3 | pages = 654–665 | date = January 2004 | pmid = 14697242 | doi = 10.1016/j.bbrc.2003.12.001 }}
• {{cite journal | vauthors = Debril MB, Gelman L, Fayard E, Annicotte JS, Rocchi S, Auwerx J | title = Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 16677–16686 | date = April 2004 | pmid = 14701856 | doi = 10.1074/jbc.M312288200 | doi-access = free }}
• {{cite journal | vauthors = Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E | title = The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter | journal = The Journal of Biological Chemistry | volume = 281 | issue = 29 | pages = 19960–19968 | date = July 2006 | pmid = 16687403 | doi = 10.1074/jbc.M603336200 | doi-access = free }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–648 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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