SMARCE1

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.

SMARCE1 has been shown to interact with Estrogen receptor alpha,{{cite journal | vauthors = Belandia B, Orford RL, Hurst HC, Parker MG | title = Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes | journal = The EMBO Journal | volume = 21 | issue = 15 | pages = 4094–103 | date = Aug 2002 | pmid = 12145209 | pmc = 126156 | doi = 10.1093/emboj/cdf412 }} SMARCB1{{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–82 | date = Oct 1996 | pmid = 8895581 | pmc = 452280 | doi = 10.1002/j.1460-2075.1996.tb00921.x }}{{cite journal | vauthors = Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR | title = Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling | journal = Cell | volume = 95 | issue = 5 | pages = 625–36 | date = Nov 1998 | pmid = 9845365 | doi = 10.1016/S0092-8674(00)81633-5 | s2cid = 3184211 | doi-access = free }} and SMARCA4.

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• {{cite journal | vauthors = Martens JA, Winston F | title = Recent advances in understanding chromatin remodeling by Swi/Snf complexes | journal = Current Opinion in Genetics & Development | volume = 13 | issue = 2 | pages = 136–42 | date = Apr 2003 | pmid = 12672490 | doi = 10.1016/S0959-437X(03)00022-4 }}
• {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–82 | date = Oct 1996 | pmid = 8895581 | pmc = 452280 | doi = 10.1002/j.1460-2075.1996.tb00921.x}}
• {{cite journal | vauthors = Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D | title = A human RNA polymerase II complex containing factors that modify chromatin structure | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5355–63 | date = Sep 1998 | pmid = 9710619 | pmc = 109120 | doi = 10.1128/MCB.18.9.5355}}
• {{cite journal | vauthors = Phelan ML, Sif S, Narlikar GJ, Kingston RE | title = Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits | journal = Molecular Cell | volume = 3 | issue = 2 | pages = 247–53 | date = Feb 1999 | pmid = 10078207 | doi = 10.1016/S1097-2765(00)80315-9 | doi-access = free }}
• {{cite journal | vauthors = Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W | title = The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 24 | pages = 13015–20 | date = Nov 2000 | pmid = 11078522 | pmc = 27170 | doi = 10.1073/pnas.240208597 | bibcode = 2000PNAS...9713015X | doi-access = free }}
• {{cite journal | vauthors = Decristofaro MF, Betz BL, Rorie CJ, Reisman DN, Wang W, Weissman BE | title = Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies | journal = Journal of Cellular Physiology | volume = 186 | issue = 1 | pages = 136–45 | date = Jan 2001 | pmid = 11147808 | doi = 10.1002/1097-4652(200101)186:1<136::AID-JCP1010>3.0.CO;2-4 | s2cid = 25016283 }}
• {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
• {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 | doi-access = free | hdl = 2066/170683 | hdl-access = free }}
• {{cite journal | vauthors = Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR | title = Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes | journal = Nature | volume = 418 | issue = 6894 | pages = 195–9 | date = Jul 2002 | pmid = 12110891 | doi = 10.1038/nature00876 | s2cid = 4406140 }}
• {{cite journal | vauthors = Belandia B, Orford RL, Hurst HC, Parker MG | title = Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes | journal = The EMBO Journal | volume = 21 | issue = 15 | pages = 4094–103 | date = Aug 2002 | pmid = 12145209 | pmc = 126156 | doi = 10.1093/emboj/cdf412 }}
• {{cite journal | vauthors = Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G | title = REST repression of neuronal genes requires components of the hSWI.SNF complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 41038–45 | date = Oct 2002 | pmid = 12192000 | doi = 10.1074/jbc.M205691200 | doi-access = free }}
• {{cite journal | vauthors = Baker KM, Wei G, Schaffner AE, Ostrowski MC | title = Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 17876–84 | date = May 2003 | pmid = 12637547 | doi = 10.1074/jbc.M209480200 | doi-access = free }}
• {{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation | journal = Molecular and Cellular Biology | volume = 23 | issue = 17 | pages = 6210–20 | date = Sep 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}
• {{cite journal | vauthors = Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F | title = Protein profile of tax-associated complexes | journal = The Journal of Biological Chemistry | volume = 279 | issue = 1 | pages = 495–508 | date = Jan 2004 | pmid = 14530271 | doi = 10.1074/jbc.M310069200 | doi-access = free }}
• {{cite journal | vauthors = Millar JK, Christie S, Porteous DJ | title = Yeast two-hybrid screens implicate DISC1 in brain development and function | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 4 | pages = 1019–25 | date = Nov 2003 | pmid = 14623284 | doi = 10.1016/j.bbrc.2003.10.101 }}

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