SMD

• Science Mission Directorate, a body within NASA
• Sharjah Museums Department, former name of the Sharjah Museums Authority
• Soil Machine Dynamics, an underwater vehicles company founded by Alan Reece

• Simian Mobile Disco, an English electronic music duo
• Slipmatt Dubs (born 1967), Breakbeat hardcore series
• Sacræ Musicæ Doctor (Doctor of Sacred Music)

• Standardized mean difference, a basis for effect size in statistics
• Sauter mean diameter, in fluid dynamics
• {{ill|Semi Metalic Disc|pt|SMD}}, audio release format developed in Brazil
• Service Mapping Description, a proposed standard for describing web services
• Stereotypic movement disorder, a motor disorder
• Storage Module Device, 1970s CDC disk drives
• Surface-mounted device, an electronic component used in surface-mount technology
• SMD LED module, a common component of an LED lamp

• Sega Mega Drive, a fourth-generation video game console
• Single-member district, a type of electoral district
• SMD High School, Srinagar, Jammu and Kashmir, India

• IATA and FAA identifier for Smith Field (Indiana) airport, Fort Wayne, Indiana, US
• National Rail station code for Stamford railway station, South Kesteven, Lincolnshire, England

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