SMG1

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.

SMG1 (gene) has been shown to interact with PRKCI{{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Mol. Cell. Biol. | volume = 16 | issue = 1 | pages = 105–14 | date = January 1996 | doi = 10.1128/mcb.16.1.105 | pmid = 8524286 | pmc = 230983 }} and UPF1.{{cite journal | vauthors = Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S | title = Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay | journal = Genes Dev. | volume = 15 | issue = 17 | pages = 2215–28 | date = September 2001 | pmid = 11544179 | pmc = 312771 | doi = 10.1101/gad.913001 }}

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• {{cite journal | vauthors = Abraham RT | title = The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways | journal = DNA Repair (Amst.) | volume = 3 | issue = 8–9 | pages = 919–25 | year = 2005 | pmid = 15279777 | doi = 10.1016/j.dnarep.2004.04.003 }}
• {{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Mol. Cell. Biol. | volume = 16 | issue = 1 | pages = 105–14 | year = 1996 | pmid = 8524286 | pmc = 230983 | doi = 10.1128/MCB.16.1.105}}
• {{cite journal | vauthors = Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT | title = Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62 | journal = Mol. Cell. Biol. | volume = 18 | issue = 5 | pages = 3069–80 | year = 1998 | pmid = 9566925 | pmc = 110686 | doi = 10.1128/mcb.18.5.3069}}
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• {{cite journal | vauthors = Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S | title = Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay | journal = Genes Dev. | volume = 15 | issue = 17 | pages = 2215–28 | year = 2001 | pmid = 11544179 | pmc = 312771 | doi = 10.1101/gad.913001 }}
• {{cite journal | vauthors = Eichler EE, Johnson ME, Alkan C, Tuzun E, Sahinalp C, Misceo D, Archidiacono N, Rocchi M | title = Divergent origins and concerted expansion of two segmental duplications on chromosome 16 | journal = J. Hered. | volume = 92 | issue = 6 | pages = 462–8 | year = 2002 | pmid = 11948212 | doi = 10.1093/jhered/92.6.462 | doi-access = free }}
• {{cite journal | vauthors = Chiu SY, Serin G, Ohara O, Maquat LE | title = Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 | journal = RNA | volume = 9 | issue = 1 | pages = 77–87 | year = 2003 | pmid = 12554878 | pmc = 1370372 | doi = 10.1261/rna.2137903 }}
• {{cite journal | vauthors = Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S | title = Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 | journal = Mol. Cell | volume = 12 | issue = 5 | pages = 1187–200 | year = 2003 | pmid = 14636577 | doi = 10.1016/S1097-2765(03)00443-X | doi-access = free }}
• {{cite journal | vauthors = Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT | title = The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells | journal = Mol. Cell | volume = 14 | issue = 5 | pages = 585–98 | year = 2004 | pmid = 15175154 | doi = 10.1016/j.molcel.2004.05.005 | doi-access = free }}
• {{cite journal | vauthors = Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S | title = Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay | journal = Genes Dev. | volume = 20 | issue = 3 | pages = 355–67 | year = 2006 | pmid = 16452507 | pmc = 1361706 | doi = 10.1101/gad.1389006 }}
• {{cite journal | vauthors = Azzalin CM, Lingner J | title = The human RNA surveillance factor UPF1 is required for S phase progression and genome stability | journal = Curr. Biol. | volume = 16 | issue = 4 | pages = 433–9 | year = 2006 | pmid = 16488880 | doi = 10.1016/j.cub.2006.01.018 | s2cid = 17197870 | doi-access = free | bibcode = 2006CBio...16..433A }}

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{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

Category:Genes on human chromosome 16

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