SMPD2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.{{cite journal | vauthors = Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W | title = Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3638–43 | date = March 1998 | pmid = 9520418 | pmc = 19888 | doi = 10.1073/pnas.95.7.3638 | bibcode = 1998PNAS...95.3638T | doi-access = free }}{{cite web | title = Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6610| accessdate = }}
References
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Further reading
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- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Sawai H, Domae N, Nagan N, Hannun YA | title = Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C | journal = The Journal of Biological Chemistry | volume = 274 | issue = 53 | pages = 38131–9 | date = December 1999 | pmid = 10608884 | doi = 10.1074/jbc.274.53.38131 | doi-access = free }}
- {{cite journal | vauthors = Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA | title = Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 24 | pages = 25101–11 | date = June 2004 | pmid = 15051724 | doi = 10.1074/jbc.M313662200 | doi-access = free }}
- {{cite journal | vauthors = Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S, Proksch E | title = Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis | journal = The Journal of Investigative Dermatology | volume = 122 | issue = 6 | pages = 1423–31 | date = June 2004 | pmid = 15175033 | doi = 10.1111/j.0022-202X.2004.22621.x | doi-access = free }}
- {{cite journal | vauthors = Jana A, Pahan K | title = Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase | journal = The Journal of Neuroscience | volume = 24 | issue = 43 | pages = 9531–40 | date = October 2004 | pmid = 15509740 | pmc = 1955476 | doi = 10.1523/JNEUROSCI.3085-04.2004 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
- {{cite journal | vauthors = Kim HT, Lee JY, Han BG, Kimm K, Oh B, Shin HD, Namkung JH, Kim E, Park T, Yang JM | title = Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans | journal = Journal of Dermatological Science | volume = 46 | issue = 2 | pages = 143–6 | date = May 2007 | pmid = 17212982 | doi = 10.1016/j.jdermsci.2006.12.001 }}
- {{cite journal | vauthors = Tani M, Hannun YA | title = Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization | journal = The Journal of Biological Chemistry | volume = 282 | issue = 13 | pages = 10047–56 | date = March 2007 | pmid = 17272284 | doi = 10.1074/jbc.M611249200 | doi-access = free }}
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