SMURF2

SMURF2 has been shown to interact with:

{{div col|colwidth=20em}}

• Mothers against decapentaplegic homolog 1,
• Mothers against decapentaplegic homolog 2,
• Mothers against decapentaplegic homolog 3,{{cite journal | vauthors = Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL | title = TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation | journal = Nature Cell Biology | volume = 3 | issue = 6 | pages = 587–95 | date = Jun 2001 | pmid = 11389444 | doi = 10.1038/35078562 | s2cid = 23270947 }}{{cite journal | vauthors = Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T | title = Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins | journal = The Journal of Biological Chemistry | volume = 284 | issue = 10 | pages = 6109–15 | date = Mar 2009 | pmid = 19122240 | doi = 10.1074/jbc.M804659200 | doi-access = free }}
• Mothers against decapentaplegic homolog 7,{{cite journal | vauthors = Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K | title = Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts | journal = The Journal of Clinical Investigation | volume = 113 | issue = 2 | pages = 253–64 | date = Jan 2004 | pmid = 14722617 | pmc = 310747 | doi = 10.1172/JCI16269 }}{{cite journal | vauthors = Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL | title = Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation | journal = Molecular Cell | volume = 6 | issue = 6 | pages = 1365–75 | date = Dec 2000 | pmid = 11163210 | doi = 10.1016/s1097-2765(00)00134-9| doi-access = free }}{{cite journal | vauthors = Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S | title = AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2 | journal = Biochemical and Biophysical Research Communications | volume = 371 | issue = 3 | pages = 395–400 | date = Jul 2008 | pmid = 18448069 | doi = 10.1016/j.bbrc.2008.04.099 }}
• SCYE1,
• SMURF1,{{cite journal | vauthors = Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T | title = Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells | journal = The Journal of Biological Chemistry | volume = 283 | issue = 51 | pages = 35660–7 | date = Dec 2008 | pmid = 18927080 | doi = 10.1074/jbc.M710496200 | doi-access = free }} and
• Ubiquitin C.{{cite journal | vauthors = Carpentier I, Coornaert B, Beyaert R | title = Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation | journal = Biochemical and Biophysical Research Communications | volume = 374 | issue = 4 | pages = 752–7 | date = Oct 2008 | pmid = 18671942 | doi = 10.1016/j.bbrc.2008.07.103 }}

{{Div col end}}

• TOP2A,{{cite journal | vauthors = Emanuelli A, Borroni AP, Apel-Sarid L, Shah P, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M | title = Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity | journal = Cancer Research | volume = 77 | issue = 16 | pages = 4217–4227 | date = Aug 2017 | pmid = 28611047 | doi = 10.1158/0008-5472.CAN-16-2828 | doi-access = free }}

{{Reflist}}

{{Refbegin | 2}}

• {{cite journal | vauthors = Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R | title = Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 3 | pages = 974–9 | date = Jan 2001 | pmid = 11158580 | pmc = 14694 | doi = 10.1073/pnas.98.3.974 | bibcode = 2001PNAS...98..974Z | doi-access = free }}
• {{cite journal | vauthors = Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL | title = Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation | journal = Molecular Cell | volume = 6 | issue = 6 | pages = 1365–75 | date = Dec 2000 | pmid = 11163210 | doi = 10.1016/S1097-2765(00)00134-9 | doi-access = free }}
• {{cite journal | vauthors = Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL | title = TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation | journal = Nature Cell Biology | volume = 3 | issue = 6 | pages = 587–95 | date = Jun 2001 | pmid = 11389444 | doi = 10.1038/35078562 | s2cid = 23270947 }}
• {{cite journal | vauthors = Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A | title = The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase | journal = British Journal of Cancer | volume = 89 | issue = 8 | pages = 1538–44 | date = Oct 2003 | pmid = 14562029 | pmc = 2394340 | doi = 10.1038/sj.bjc.6601301 }}
• {{cite journal | vauthors = Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K | title = Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts | journal = The Journal of Clinical Investigation | volume = 113 | issue = 2 | pages = 253–64 | date = Jan 2004 | pmid = 14722617 | pmc = 310747 | doi = 10.1172/JCI16269 }}
• {{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8 | date = Mar 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 | s2cid = 37253372 | doi-access = }}
• {{cite journal | vauthors = Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC | title = Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 29409–17 | date = Jul 2004 | pmid = 15138260 | doi = 10.1074/jbc.M313120200 | doi-access = free }}
• {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
• {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
• {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
• {{cite journal | vauthors = Zhang H, Cohen SN | title = Smurf2 up-regulation activates telomere-dependent senescence | journal = Genes & Development | volume = 18 | issue = 24 | pages = 3028–40 | date = Dec 2004 | pmid = 15574587 | pmc = 535914 | doi = 10.1101/gad.1253004 }}
• {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = Mar 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }}
• {{cite journal | vauthors = Ohashi N, Yamamoto T, Uchida C, Togawa A, Fukasawa H, Fujigaki Y, Suzuki S, Kitagawa K, Hattori T, Oda T, Hayashi H, Hishida A, Kitagawa M | title = Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta | journal = FEBS Letters | volume = 579 | issue = 12 | pages = 2557–63 | date = May 2005 | pmid = 15862290 | doi = 10.1016/j.febslet.2005.03.069 | hdl = 10271/283 | s2cid = 38498506 | hdl-access = free }}
• {{cite journal | vauthors = Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL | title = Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain | journal = Molecular Cell | volume = 19 | issue = 3 | pages = 297–308 | date = Aug 2005 | pmid = 16061177 | doi = 10.1016/j.molcel.2005.06.028 | doi-access = free }}
• {{cite journal | vauthors = Chong PA, Lin H, Wrana JL, Forman-Kay JD | title = An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 25 | pages = 17069–75 | date = Jun 2006 | pmid = 16641086 | doi = 10.1074/jbc.M601493200 | doi-access = free }}
• {{cite journal | vauthors = Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD | title = Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain | journal = Cell | volume = 130 | issue = 4 | pages = 651–62 | date = Aug 2007 | pmid = 17719543 | doi = 10.1016/j.cell.2007.06.050 | s2cid = 16684837 | doi-access = free }}

{{Refend}}

{{PDB Gallery|geneid=64750}}

{{Gene-17-stub}}