Login
Login

SNRPD3

{{cs1 config|name-list-style=vanc}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.{{cite journal | vauthors = Lehmeier T, Foulaki K, Lührmann R | title = Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5 | journal = Nucleic Acids Res | volume = 18 | issue = 22 | pages = 6475–84 | date = January 1991 | pmid = 1701240 | pmc = 332598 | doi = 10.1093/nar/18.22.6475 }}{{cite journal | vauthors = Lehmeier T, Raker V, Hermann H, Lührmann R | title = cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 25 | pages = 12317–21 | date = January 1995 | pmid = 7527560 | pmc = 45428 | doi = 10.1073/pnas.91.25.12317 | bibcode = 1994PNAS...9112317L | doi-access = free }}{{cite web | title = Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6634| accessdate = }}

Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.

Interactions

SNRPD3 has been shown to interact with:

  • CDC5L,{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
  • CLNS1A,{{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | date = Dec 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
  • DDX20,{{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | date = Dec 1999 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181}} and
  • Protein arginine methyltransferase 5.

References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal | vauthors = Liu Q, Fischer U, Wang F, Dreyfuss G | title = The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | journal = Cell | volume = 90 | issue = 6 | pages = 1013–21 | year = 1997 | pmid = 9323129 | doi = 10.1016/S0092-8674(00)80367-0 | doi-access = free }}
  • {{cite journal | vauthors = Fury MG, Zhang W, Christodoulopoulos I, Zieve GW | title = Multiple protein: protein interactions between the snRNP common core proteins | journal = Exp. Cell Res. | volume = 237 | issue = 1 | pages = 63–9 | year = 1998 | pmid = 9417867 | doi = 10.1006/excr.1997.3750 }}
  • {{cite journal | vauthors = Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K | title = Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs | journal = Cell | volume = 96 | issue = 3 | pages = 375–87 | year = 1999 | pmid = 10025403 | doi = 10.1016/S0092-8674(00)80550-4 | doi-access = free }}
  • {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G | title = Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1181–94 | year = 2000 | pmid = 10601333 | pmc = 2168095 | doi = 10.1083/jcb.147.6.1181 }}
  • {{cite journal | vauthors = Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G | title = Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli | journal = J. Cell Biol. | volume = 148 | issue = 6 | pages = 1177–86 | year = 2000 | pmid = 10725331 | pmc = 2174312 | doi = 10.1083/jcb.148.6.1177 }}
  • {{cite journal | vauthors = Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R | title = The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 17122–9 | year = 2000 | pmid = 10747894 | doi = 10.1074/jbc.M000300200 | doi-access = free | hdl = 11858/00-001M-0000-0012-F7F0-E | hdl-access = free }}
  • {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | year = 2001 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
  • {{cite journal | vauthors = Urlaub H, Raker VA, Kostka S, Lührmann R | title = Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure | journal = EMBO J. | volume = 20 | issue = 1–2 | pages = 187–96 | year = 2001 | pmid = 11226169 | pmc = 140196 | doi = 10.1093/emboj/20.1.187 }}
  • {{cite journal | vauthors = Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G | title = SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets | journal = Mol. Cell | volume = 7 | issue = 5 | pages = 1111–7 | year = 2001 | pmid = 11389857 | doi = 10.1016/S1097-2765(01)00244-1 | doi-access = free }}
  • {{cite journal | vauthors = Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G | title = The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins | journal = Mol. Cell. Biol. | volume = 21 | issue = 24 | pages = 8289–300 | year = 2001 | pmid = 11713266 | pmc = 99994 | doi = 10.1128/MCB.21.24.8289-8300.2001 }}
  • {{cite journal | vauthors = Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 5631–6 | year = 2002 | pmid = 11714716 | doi = 10.1074/jbc.M109448200 | doi-access = free }}
  • {{cite journal | vauthors = Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U | title = Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln | journal = Curr. Biol. | volume = 11 | issue = 24 | pages = 1990–4 | year = 2002 | pmid = 11747828 | doi = 10.1016/S0960-9822(01)00592-9 | hdl = 11858/00-001M-0000-0012-F501-7 | s2cid = 14742376 | hdl-access = free }}
  • {{cite journal | vauthors = Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G | title = Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7540–5 | year = 2002 | pmid = 11748230 | doi = 10.1074/jbc.M110141200 | doi-access = free }}
  • {{cite journal | vauthors = Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G | title = A novel WD repeat protein component of the methylosome binds Sm proteins | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8243–7 | year = 2002 | pmid = 11756452 | doi = 10.1074/jbc.M109984200 | doi-access = free }}
  • {{cite journal | vauthors = Fong YW, Zhou Q | title = Stimulatory effect of splicing factors on transcriptional elongation | journal = Nature | volume = 414 | issue = 6866 | pages = 929–33 | year = 2002 | pmid = 11780068 | doi = 10.1038/414929a | s2cid = 1518837 }}
  • {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | doi-access = free }}
  • {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
  • {{cite journal | vauthors = Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G | title = Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 31957–62 | year = 2002 | pmid = 12065586 | doi = 10.1074/jbc.M203478200 | doi-access = free }}

{{Refend}}

{{PDB Gallery|geneid=6634}}

{{Ribonucleoproteins}}

{{Gene-22-stub}}