SNX1

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.{{cite web | title = Entrez Gene: sorting nexin 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6642 }}

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• {{cite journal |vauthors=Parks WT, Frank DB, Huff C, etal |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332–9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200 |doi-access= free }}
• {{cite journal |vauthors=Cozier GE, Carlton J, McGregor AH, etal |title=The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48730–6 |year= 2002 |pmid= 12198132 |doi= 10.1074/jbc.M206986200 |doi-access= free }}
• {{cite journal |vauthors=Shank BB, Wiley HS, Kurten RC |title=Structural and functional characterization of the human gene for sorting nexin 1 (SNX1). |journal=DNA Cell Biol. |volume=20 |issue= 5 |pages= 287–96 |year= 2001 |pmid= 11410165 |doi= 10.1089/104454901750232481 }}
• {{cite journal |vauthors=Liu H, Liu ZQ, Chen CX, etal |title=Inhibitory regulation of EGF receptor degradation by sorting nexin 5. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 2 |pages= 537–46 |year= 2006 |pmid= 16487940 |doi= 10.1016/j.bbrc.2006.01.179 }}
• {{cite journal |vauthors=Bryant DM, Kerr MC, Hammond LA, etal |title=EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. |journal=J. Cell Sci. |volume=120 |issue= Pt 10 |pages= 1818–28 |year= 2007 |pmid= 17502486 |doi= 10.1242/jcs.000653 |s2cid=24175340 |doi-access= }}
• {{cite journal |vauthors=Simpson F, Martin S, Evans TM, etal |title=A novel hook-related protein family and the characterization of hook-related protein 1. |journal=Traffic |volume=6 |issue= 6 |pages= 442–58 |year= 2005 |pmid= 15882442 |doi= 10.1111/j.1600-0854.2005.00289.x |s2cid=25389776 |doi-access=free }}
• {{cite journal |vauthors=Imabayashi H, Mori T, Gojo S, etal |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=10.1016/S0014-4827(03)00130-7 }}
• {{cite journal |vauthors=Zhong Q, Watson MJ, Lazar CS, etal |title=Determinants of the endosomal localization of sorting nexin 1. |journal=Mol. Biol. Cell |volume=16 |issue= 4 |pages= 2049–57 |year= 2005 |pmid= 15673616 |doi= 10.1091/mbc.E04-06-0504 |pmc=1073682 }}
• {{cite journal |vauthors=Mari M, Bujny MV, Zeuschner D, etal |title=SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. |journal=Traffic |volume=9 |issue= 3 |pages= 380–93 |year= 2008 |pmid= 18088323 |doi= 10.1111/j.1600-0854.2007.00686.x |s2cid=31922423 |doi-access=free }}
• {{cite journal |vauthors=Nguyen LN, Holdren MS, Nguyen AP, etal |title=Sorting nexin 1 down-regulation promotes colon tumorigenesis. |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6952–9 |year= 2006 |pmid= 17145813 |doi= 10.1158/1078-0432.CCR-06-0317 |hdl=11336/31768 |doi-access=free |hdl-access=free }}
• {{cite journal |vauthors=Pons V, Hullin-Matsuda F, Nauze M, etal |title=Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. |journal=J. Biol. Chem. |volume=278 |issue= 23 |pages= 21155–61 |year= 2003 |pmid= 12657642 |doi= 10.1074/jbc.M211008200 |doi-access= free }}
• {{cite journal |vauthors=Rojas R, Kametaka S, Haft CR, Bonifacino JS |title=Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. |journal=Mol. Cell. Biol. |volume=27 |issue= 3 |pages= 1112–24 |year= 2007 |pmid= 17101778 |doi= 10.1128/MCB.00156-06 |pmc=1800681 }}
• {{cite journal |vauthors=Gullapalli A, Wolfe BL, Griffin CT, etal |title=An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. |journal=Mol. Biol. Cell |volume=17 |issue= 3 |pages= 1228–38 |year= 2006 |pmid= 16407403 |doi= 10.1091/mbc.E05-09-0899 |pmc=1382312 }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
• {{cite journal |vauthors=Zhong Q, Lazar CS, Tronchère H|title=Endosomal localization and function of sorting nexin 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6767–72 |year= 2002 |pmid= 11997453 |doi= 10.1073/pnas.092142699 |pmc=124477 |bibcode=2002PNAS...99.6767Z |display-authors=etal|doi-access=free }}
• {{cite journal |vauthors=Wang Y, Zhou Y, Szabo K, etal |title=Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. |journal=Mol. Biol. Cell |volume=13 |issue= 6 |pages= 1965–76 |year= 2002 |pmid= 12058063 |doi= 10.1091/mbc.E01-11-0131 |pmc=117618 }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Carlton J, Bujny M, Peter BJ, etal |title=Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. |journal=Curr. Biol. |volume=14 |issue= 20 |pages= 1791–800 |year= 2004 |pmid= 15498486 |doi= 10.1016/j.cub.2004.09.077 |hdl=1874/12362 |s2cid=10366991 |hdl-access=free }}
• {{cite journal |vauthors=Kurten RC, Eddington AD, Chowdhury P, etal |title=Self-assembly and binding of a sorting nexin to sorting endosomes. |journal=J. Cell Sci. |volume=114 |issue= Pt 9 |pages= 1743–56 |year= 2001 |doi=10.1242/jcs.114.9.1743 |pmid= 11309204 |doi-access=free }}

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• {{MeshName|sorting+nexins}}

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{{Sorting nexins}}

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