SNX13
{{Short description|Gene of the species Homo sapiens}}
{{Infobox_gene}}
Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.{{cite journal | vauthors = Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA | title = A large family of endosome-localized proteins related to sorting nexin 1 | journal = The Biochemical Journal | volume = 358 | issue = Pt 1 | pages = 7–16 | date = August 2001 | pmid = 11485546 | pmc = 1222026 | doi = 10.1042/0264-6021:3580007 }}{{cite journal | vauthors = Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG | title = RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking | journal = Science | volume = 294 | issue = 5548 | pages = 1939–42 | date = November 2001 | pmid = 11729322 | doi = 10.1126/science.1064757 | bibcode = 2001Sci...294.1939Z | s2cid = 85169394 }}{{cite web | title = Entrez Gene: SNX13 sorting nexin 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23161}}
Function
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delays lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.
References
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Further reading
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- {{cite journal | vauthors = Worby CA, Dixon JE | title = Sorting out the cellular functions of sorting nexins | journal = Nature Reviews. Molecular Cell Biology | volume = 3 | issue = 12 | pages = 919–31 | date = December 2002 | pmid = 12461558 | doi = 10.1038/nrm974 | s2cid = 36361630 }}
- {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = October 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 | doi-access = free }}
- {{cite journal | vauthors = Kosan C, Kunz J | title = Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region | journal = Cytogenetic and Genome Research | volume = 97 | issue = 3–4 | pages = 167–70 | year = 2003 | pmid = 12438708 | doi = 10.1159/000066618 | s2cid = 27223779 }}
- {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 | doi-access = free }}
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{{Sorting nexins}}
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