SNX27
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Sorting nexin family member 27, also known as SNX27, is a human gene.{{cite web | title = Entrez Gene: SNX27 sorting nexin family member 27| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81609}}
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
References
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Further reading
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- {{cite journal | vauthors = Worby CA, Dixon JE | title = Sorting out the cellular functions of sorting nexins | journal = Nature Reviews. Molecular Cell Biology | volume = 3 | issue = 12 | pages = 919–31 | date = December 2002 | pmid = 12461558 | doi = 10.1038/nrm974 | s2cid = 36361630 }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O | title = Characterization of cDNA clones in size-fractionated cDNA libraries from human brain | journal = DNA Research | volume = 4 | issue = 5 | pages = 345–9 | date = October 1997 | pmid = 9455484 | doi = 10.1093/dnares/4.5.345 | doi-access = free }}
- {{cite journal | vauthors = Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA | title = A large family of endosome-localized proteins related to sorting nexin 1 | journal = The Biochemical Journal | volume = 358 | issue = Pt 1 | pages = 7–16 | date = August 2001 | pmid = 11485546 | pmc = 1222026 | doi = 10.1042/0264-6021:3580007 }}
- {{cite journal | vauthors = Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF | title = Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin | journal = Molecular Biology of the Cell | volume = 15 | issue = 7 | pages = 3095–105 | date = July 2004 | pmid = 15121882 | pmc = 452567 | doi = 10.1091/mbc.E04-02-0143 }}
- {{cite journal | vauthors = Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J | title = New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting | journal = Journal of Cell Science | volume = 117 | issue = Pt 22 | pages = 5367–79 | date = October 2004 | pmid = 15466885 | doi = 10.1242/jcs.01379 | doi-access = free }}
- {{cite journal | vauthors = Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I | title = Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 6 | pages = 1073–87 | date = June 2007 | pmid = 17351151 | doi = 10.1074/mcp.M700047-MCP200 | doi-access = free }}
- {{cite journal | vauthors = MacNeil AJ, Mansour M, Pohajdak B | title = Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes | journal = Biochemical and Biophysical Research Communications | volume = 359 | issue = 4 | pages = 848–53 | date = August 2007 | pmid = 17577583 | doi = 10.1016/j.bbrc.2007.05.162 }}
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{{Sorting nexins}}
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