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SNX4

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.{{cite journal |vauthors=Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI | title = Identification of a family of sorting nexin molecules and characterization of their association with receptors | journal = Mol Cell Biol | volume = 18 | issue = 12 | pages = 7278–87 |date=Dec 1998 | pmid = 9819414 | pmc = 109309 | doi = 10.1128/mcb.18.12.7278}}{{cite web | title = Entrez Gene: SNX4 sorting nexin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8723| accessdate = }}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.

Interactions

SNX4 has been shown to interact with BIN1.{{cite journal |last=Leprince |first=Corinne |author2=Le Scolan Erwan |author3=Meunier Brigitte |author4=Fraisier Vincent |author5=Brandon Nathalie |author6=De Gunzburg Jean |author7=Camonis Jacques |date=May 2003 |title=Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking |journal=J. Cell Sci. |volume=116 |issue=Pt 10 |pages=1937–48 |location = England| issn = 0021-9533| pmid = 12668730 |doi = 10.1242/jcs.00403 |doi-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Traer CJ, Rutherford AC, Palmer KJ, etal |title=SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. |journal=Nat. Cell Biol. |volume=9 |issue= 12 |pages= 1370–80 |year= 2008 |pmid= 17994011 |doi= 10.1038/ncb1656 |s2cid=23816176 }}
  • {{cite journal |vauthors=Skånland SS, Wälchli S, Utskarpen A, etal |title=Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. |journal=Traffic |volume=8 |issue= 3 |pages= 297–309 |year= 2007 |pmid= 17319803 |doi= 10.1111/j.1600-0854.2006.00527.x |hdl=10852/11339 |s2cid=21600584 |hdl-access=free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Leprince C, Le Scolan E, Meunier B, etal |title=Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. |journal=J. Cell Sci. |volume=116 |issue= Pt 10 |pages= 1937–48 |year= 2004 |pmid= 12668730 |doi= 10.1242/jcs.00403 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Parks WT, Frank DB, Huff C, etal |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332–9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200 |doi-access= free }}

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{{Sorting nexins}}

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