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SNX5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.{{cite journal|author1=Otsuki T|author2=Kajigaya S|author3=Ozawa K|author4=Liu JM|title=SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein|journal=Biochem Biophys Res Commun|volume=265|issue=3|pages=630–5|date=Jan 2000|pmid=10600472|doi=10.1006/bbrc.1999.1731}}{{cite journal|author1=Wassmer T|author2=Attar N|author3=Bujny MV|author4=Oakley J|author5=Traer CJ|author6=Cullen PJ|title=A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer|journal=J Cell Sci|volume=120|issue=Pt 1|pages=45–54|date=Dec 2006|pmid=17148574|doi=10.1242/jcs.03302|doi-access=free}}{{cite web|title=Entrez Gene: SNX5 sorting nexin 5|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27131}}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.

Interactions

SNX5 has been shown to interact with FANCA.

References

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Further reading

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  • {{cite journal|author1=Maruyama K|author2=Sugano S|title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides|journal=Gene|volume=138|issue=1–2|pages=171–4|year=1994|pmid=8125298|doi=10.1016/0378-1119(94)90802-8}}
  • {{cite journal|vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal|title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library|journal=Gene|volume=200|issue=1–2|pages=149–56|year=1997|pmid=9373149|doi=10.1016/S0378-1119(97)00411-3}}
  • {{cite journal|vauthors=Teasdale RD, Loci D, Houghton F, etal|title=A large family of endosome-localized proteins related to sorting nexin 1|journal=Biochem. J.|volume=358|issue=Pt 1|pages=7–16|year=2001|pmid=11485546|doi=10.1042/0264-6021:3580007|pmc=1222026}}
  • {{cite journal|vauthors=Deloukas P, Matthews LH, Ashurst J, etal|title=The DNA sequence and comparative analysis of human chromosome 20|journal=Nature|volume=414|issue=6866|pages=865–71|year=2002|pmid=11780052|doi=10.1038/414865a|bibcode=2001Natur.414..865D |doi-access=free}}
  • {{cite journal|vauthors=Strausberg RL, Feingold EA, Grouse LH, etal|title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences|journal=Proc. Natl. Acad. Sci. U.S.A.|volume=99|issue=26|pages=16899–903|year=2003|pmid=12477932|doi=10.1073/pnas.242603899|pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free}}
  • {{cite journal|vauthors=Ota T, Suzuki Y, Nishikawa T, etal|title=Complete sequencing and characterization of 21,243 full-length human cDNAs|journal=Nat. Genet.|volume=36|issue=1|pages=40–5|year=2004|pmid=14702039|doi=10.1038/ng1285|doi-access=free}}
  • {{cite journal|vauthors=Towler MC, Gleeson PA, Hoshino S, etal|title=Clathrin Isoform CHC22, a Component of Neuromuscular and Myotendinous Junctions, Binds Sorting Nexin 5 and Has Increased Expression during Myogenesis and Muscle Regeneration|journal=Mol. Biol. Cell|volume=15|issue=7|pages=3181–95|year=2005|pmid=15133132|doi=10.1091/mbc.E04-03-0249|pmc=452575}}
  • {{cite journal|vauthors=Gerhard DS, Wagner L, Feingold EA, etal|title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)|journal=Genome Res.|volume=14|issue=10B|pages=2121–7|year=2004|pmid=15489334|doi=10.1101/gr.2596504|pmc=528928}}
  • {{cite journal|vauthors=Merino-Trigo A, Kerr MC, Houghton F, etal|title=Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation|journal=J. Cell Sci.|volume=117|issue=Pt 26|pages=6413–24|year=2005|pmid=15561769|doi=10.1242/jcs.01561|s2cid=39278533 |doi-access=}}
  • {{cite journal|vauthors=Rual JF, Venkatesan K, Hao T, etal|title=Towards a proteome-scale map of the human protein-protein interaction network|journal=Nature|volume=437|issue=7062|pages=1173–8|year=2005|pmid=16189514|doi=10.1038/nature04209|bibcode=2005Natur.437.1173R|s2cid=4427026}}

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{{Sorting nexins}}

Category:Genes mutated in mice

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