SNX6

{{infobox protein

| Name = sorting nexin 6

| caption =

| image =

| width =

| HGNCid = 14970

| Symbol = SNX6

| AltSymbols =

| EntrezGene = 58533

| OMIM = 606098

| RefSeq = NM_021249

| UniProt = Q9UNH7

| PDB =

| ECnumber =

| Chromosome = 14

| Arm = q

| Band = 13

| LocusSupplementaryData =

}}

Sorting Nexin 6 also known as SNX6 is a well-conserved membrane-associated protein belonging to the sorting nexin family that is a component of the retromer complex.{{cite journal | vauthors = Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ | title = A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer | journal = J. Cell Sci. | volume = 120 | issue = Pt 1 | pages = 45–54 |date=January 2007 | pmid = 17148574 | doi = 10.1242/jcs.03302 | doi-access = free }} The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus.{{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19332–9 |date=June 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 | doi-access = free }} SNX6 has been shown to associate with TRAF4.{{cite journal | vauthors = Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, Iguchi-Ariga SM | title = Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus | journal = FEBS Lett. | volume = 506 | issue = 1 | pages = 33–8 |date=September 2001 | pmid = 11591366 | doi = 10.1016/S0014-5793(01)02881-2 | doi-access = free }}

==References==