SOCS2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.{{cite journal | vauthors = Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A | display-authors = 6 | title = Cloning and characterization of novel CIS family genes | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 439–446 | date = October 1997 | pmid = 9344848 | doi = 10.1006/bbrc.1997.7484 }}{{cite journal | vauthors = Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T | display-authors = 6 | title = Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 | journal = Biochemical and Biophysical Research Communications | volume = 237 | issue = 1 | pages = 79–83 | date = August 1997 | pmid = 9266833 | doi = 10.1006/bbrc.1997.7080 }}{{cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835}}

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.{{cite journal | vauthors = Dey BR, Spence SL, Nissley P, Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 37 | pages = 24095–24101 | date = September 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | doi-access = free }} Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.{{cite journal | vauthors = Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS | display-authors = 6 | title = Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b) | journal = Molecular Endocrinology | volume = 16 | issue = 6 | pages = 1394–1406 | date = June 2002 | pmid = 12040024 | doi = 10.1210/mend.16.6.0845 | doi-access = free }}

Interactions

SOCS2 has been shown to interact with insulin-like growth factor 1 receptor and erythropoietin receptor.{{cite journal | vauthors = Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J | title = Design and application of a cytokine-receptor-based interaction trap | journal = Nature Cell Biology | volume = 3 | issue = 12 | pages = 1114–1119 | date = December 2001 | pmid = 11781573 | doi = 10.1038/ncb1201-1114 | s2cid = 10228882 }} Additionally, it acts as a substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex.{{cite journal | vauthors = Kung WW, Ramachandran S, Makukhin N, Bruno E, Ciulli A | title = Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase | journal = Nature Communications | volume = 10 | issue = 1 | pages = 2534 | date = June 2019 | pmid = 31182716 | doi = 10.1038/s41467-019-10190-4 | pmc = 6557900 | bibcode = 2019NatCo..10.2534K }} It is under investigation for use in targeted protein degradation.{{Cite journal |display-authors=6 |vauthors=Ramachandran S, Makukhin N, Haubrich K, Nagala M, Forrester B, Lynch D, Casement R, Testa A, Bruno E, Gitto R, Ciulli A |date=2022-10-18 |title=Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2 |journal=Nature Communications |volume=14 |issue=1 |pages=6345 |doi=10.1038/s41467-023-41894-3|pmid=37816714 |pmc=10564737 |doi-access=free }}

References

{{cite journal | vauthors = Lopaczynski W | title = Differential regulation of signaling pathways for insulin and insulin-like growth factor I | journal = Acta Biochimica Polonica | volume = 46 | issue = 1 | pages = 51–60 | year = 1999 | pmid = 10453981 | doi = 10.18388/abp.1999_4183 | doi-access = free }}
{{cite journal | vauthors = Wang J, Campbell IL | title = Cytokine signaling in the brain: putting a SOCS in it? | journal = Journal of Neuroscience Research | volume = 67 | issue = 4 | pages = 423–427 | date = February 2002 | pmid = 11835308 | doi = 10.1002/jnr.10145 | s2cid = 33269663 | doi-access = free }}
{{cite journal | vauthors = Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends in Biochemical Sciences | volume = 27 | issue = 5 | pages = 235–241 | date = May 2002 | pmid = 12076535 | doi = 10.1016/S0968-0004(02)02085-6 }}
{{cite journal | vauthors = Pezet A, Buteau H, Kelly PA, Edery M | title = The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor | journal = Molecular and Cellular Endocrinology | volume = 129 | issue = 2 | pages = 199–208 | date = May 1997 | pmid = 9202403 | doi = 10.1016/S0303-7207(97)00063-4 | s2cid = 10606236 }}
{{cite journal | vauthors = Dey BR, Spence SL, Nissley P, Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 37 | pages = 24095–24101 | date = September 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | doi-access = free }}
{{cite journal | vauthors = Pezet A, Favre H, Kelly PA, Edery M | title = Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 35 | pages = 24497–24502 | date = August 1999 | pmid = 10455112 | doi = 10.1074/jbc.274.35.24497 | doi-access = free }}
{{cite journal | vauthors = Yandava CN, Pillari A, Drazen JM | title = Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively | journal = Genomics | volume = 61 | issue = 1 | pages = 108–111 | date = October 1999 | pmid = 10512686 | doi = 10.1006/geno.1999.5937 }}
{{cite journal | vauthors = Ram PA, Waxman DJ | title = SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms | journal = The Journal of Biological Chemistry | volume = 274 | issue = 50 | pages = 35553–35561 | date = December 1999 | pmid = 10585430 | doi = 10.1074/jbc.274.50.35553 | doi-access = free }}
{{cite journal | vauthors = Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, Hilton DJ, Alexander WS | display-authors = 6 | title = Gigantism in mice lacking suppressor of cytokine signalling-2 | journal = Nature | volume = 405 | issue = 6790 | pages = 1069–1073 | date = June 2000 | pmid = 10890450 | doi = 10.1038/35016611 | s2cid = 13750159 | bibcode = 2000Natur.405.1069M }}
{{cite journal | vauthors = Shen X, Hong F, Nguyen VA, Gao B | title = IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3 | journal = FEBS Letters | volume = 480 | issue = 2–3 | pages = 132–136 | date = September 2000 | pmid = 11034314 | doi = 10.1016/S0014-5793(00)01905-0 | s2cid = 84290049 | doi-access = free }}
{{cite journal | vauthors = Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J | title = Design and application of a cytokine-receptor-based interaction trap | journal = Nature Cell Biology | volume = 3 | issue = 12 | pages = 1114–1119 | date = December 2001 | pmid = 11781573 | doi = 10.1038/ncb1201-1114 | s2cid = 10228882 }}
{{cite journal | vauthors = Schultheis B, Carapeti-Marootian M, Hochhaus A, Weisser A, Goldman JM, Melo JV | title = Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism | journal = Blood | volume = 99 | issue = 5 | pages = 1766–1775 | date = March 2002 | pmid = 11861294 | doi = 10.1182/blood.V99.5.1766 | doi-access = free }}
{{cite journal | vauthors = Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD | title = Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 3 | pages = 1094–1097 | date = March 2002 | pmid = 11889171 | doi = 10.1210/jcem.87.3.8463 | doi-access = free }}
{{cite journal | vauthors = Biener E, Maurice S, Sandowski Y, Cohen Y, Gusakowsky EE, Hooghe R, Yoshimura A, Livnah O, Gertler A | display-authors = 6 | title = Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization | journal = Protein Expression and Purification | volume = 25 | issue = 2 | pages = 305–312 | date = July 2002 | pmid = 12135564 | doi = 10.1016/S1046-5928(02)00013-X }}

External links

{{MeshName|SOCS2+protein,+human}}

SOCS2

Interactions

References

Further reading

External links