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SOCS7

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.{{cite journal | vauthors = Matuoka K, Miki H, Takahashi K, Takenawa T | title = A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 488–92 | date = Oct 1997 | pmid = 9344857 | doi = 10.1006/bbrc.1997.7492 }}{{cite journal | vauthors = Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends in Biochemical Sciences | volume = 27 | issue = 5 | pages = 235–41 | date = May 2002 | pmid = 12076535 | doi = 10.1016/S0968-0004(02)02085-6 }}{{cite web | title = Entrez Gene: SOCS7 suppressor of cytokine signaling 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837}}

Interactions

SOCS7 has been shown to interact with NCK1.

References

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Further reading

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  • {{cite journal | vauthors = Cooney RN | title = Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway | journal = Shock | volume = 17 | issue = 2 | pages = 83–90 | date = Feb 2002 | pmid = 11837794 | doi = 10.1097/00024382-200202000-00001 | s2cid = 40940132 | doi-access = free }}
  • {{cite journal | vauthors = Wormald S, Hilton DJ | title = Inhibitors of cytokine signal transduction | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 821–4 | date = Jan 2004 | pmid = 14607831 | doi = 10.1074/jbc.R300030200 | s2cid = 3469978 | url = http://espace.library.uq.edu.au/view/UQ:195698/UQ195698_OA.pdf | doi-access = free }}
  • {{cite journal | vauthors = Fujimoto M, Naka T | title = Regulation of cytokine signaling by SOCS family molecules | journal = Trends in Immunology | volume = 24 | issue = 12 | pages = 659–66 | date = Dec 2003 | pmid = 14644140 | doi = 10.1016/j.it.2003.10.008 }}
  • {{cite journal | vauthors = Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA | title = Twenty proteins containing a C-terminal SOCS box form five structural classes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 1 | pages = 114–9 | date = Jan 1998 | pmid = 9419338 | pmc = 18144 | doi = 10.1073/pnas.95.1.114 | bibcode = 1998PNAS...95..114H | doi-access = free }}
  • {{cite journal | vauthors = Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R | title = Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines | journal = Journal of Neuroimmunology | volume = 109 | issue = 1 | pages = 34–9 | date = Sep 2000 | pmid = 10969179 | doi = 10.1016/S0165-5728(00)00300-3 | s2cid = 23752435 }}
  • {{cite journal | vauthors = Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS | title = SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation | journal = Molecular and Cellular Biology | volume = 22 | issue = 13 | pages = 4567–78 | date = Jul 2002 | pmid = 12052866 | pmc = 133908 | doi = 10.1128/MCB.22.13.4567-4578.2002 }}
  • {{cite journal | vauthors = Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL | title = The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin | journal = Experimental Cell Research | volume = 298 | issue = 1 | pages = 239–48 | date = Aug 2004 | pmid = 15242778 | doi = 10.1016/j.yexcr.2004.04.002 }}
  • {{cite journal | vauthors = Martens N, Uzan G, Wery M, Hooghe R, Hooghe-Peters EL, Gertler A | title = Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation | journal = The Journal of Biological Chemistry | volume = 280 | issue = 14 | pages = 13817–23 | date = Apr 2005 | pmid = 15677474 | doi = 10.1074/jbc.M411596200 | doi-access = free }}
  • {{cite journal | vauthors = Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB | title = Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans | journal = The Journal of Clinical Investigation | volume = 115 | issue = 9 | pages = 2462–71 | date = Sep 2005 | pmid = 16127460 | pmc = 1190369 | doi = 10.1172/JCI23853 }}
  • {{cite journal | vauthors = Kremer BE, Adang LA, Macara IG | title = Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 | journal = Cell | volume = 130 | issue = 5 | pages = 837–50 | date = Sep 2007 | pmid = 17803907 | pmc = 2085444 | doi = 10.1016/j.cell.2007.06.053 }}

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{{JAK-STAT signaling pathway}}

Category:Genes mutated in mice

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