SOX11

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.{{cite journal | vauthors = Haslinger A, Schwarz TJ, Covic M, Lie DC | title = Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis | journal = The European Journal of Neuroscience | volume = 29 | issue = 11 | pages = 2103–14 | date = Jun 2009 | pmid = 19490090 | doi = 10.1111/j.1460-9568.2009.06768.x | s2cid = 42742018 }} Tuj1 and Tead2 are suggested as direct target of Sox11.{{cite journal | vauthors = Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J | title = The establishment of neuronal properties is controlled by Sox4 and Sox11 | journal = Genes & Development | volume = 20 | issue = 24 | pages = 3475–86 | date = Dec 2006 | pmid = 17182872 | pmc = 1698453 | doi = 10.1101/gad.403406 }}{{cite journal | vauthors = Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V | title = Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors | journal = Nature Communications | volume = 1 | issue = 1 | pages = 9 | date = Apr 2010 | pmid = 20596238 | pmc = 2892298 | doi = 10.1038/ncomms1008 | bibcode = 2010NatCo...1....9B }}{{cite journal | vauthors = Larson BL, Ylostalo J, Lee RH, Gregory C, Prockop DJ | title = Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells | journal = Tissue Engineering. Part A | volume = 16 | issue = 11 | pages = 3385–94 | date = Nov 2010 | pmc = 2965191 | doi = 10.1089/ten.tea.2010.0085 | pmid = 20626275 }}

Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.{{cite web|url=https://www.pathologyoutlines.com/topic/stainssox11.html|title=Stains & CD markers - SOX11|website=Pathology Outlines|author=Anna Dusenbery, M.D., Mark R. Wick, M.D.}} Topic Completed: 1 January 2018. Minor changes: 12 August 2021

Mutations in SOX11 are associated with Coffin–Siris syndrome{{cite journal | vauthors = Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N | title = De novo SOX11 mutations cause Coffin-Siris syndrome | journal = Nature Communications | volume = 5 | pages = 4011 | year = 2014 | pmid = 24886874 | doi = 10.1038/ncomms5011 | bibcode = 2014NatCo...5.4011T | doi-access = free }} and mantle cell lymphoma.{{Cite journal|last=Vose|first=Julie M.|title=Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management|journal=American Journal of Hematology|volume=92|issue=8|pages=806–813|date=August 2017|doi=10.1002/ajh.24797|issn=1096-8652|pmid=28699667|doi-access=free}}

• SOX genes

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• {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 4 | pages = 441–6 | date = Aug 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
• {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = Aug 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X | doi-access = free }}
• {{cite journal | vauthors = Gozé C, Poulat F, Berta P | title = Partial cloning of SOX-11 and SOX-12, two new human SOX genes | journal = Nucleic Acids Research | volume = 21 | issue = 12 | pages = 2943 | date = Jun 1993 | pmid = 8332506 | pmc = 309692 | doi = 10.1093/nar/21.12.2943 }}
• {{cite journal | vauthors = Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M | title = Cooperative function of POU proteins and SOX proteins in glial cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 26 | pages = 16050–7 | date = Jun 1998 | pmid = 9632656 | doi = 10.1074/jbc.273.26.16050 | doi-access = free }}
• {{cite journal | vauthors = Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M | title = Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region | journal = DNA Research | volume = 6 | issue = 5 | pages = 357–60 | date = Oct 1999 | pmid = 10574465 | doi = 10.1093/dnares/6.5.357 | doi-access = free }}
• {{cite journal | vauthors = Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ | title = Differential expression of SOX4 and SOX11 in medulloblastoma | journal = Journal of Neuro-Oncology | volume = 57 | issue = 3 | pages = 201–14 | date = May 2002 | pmid = 12125983 | doi = 10.1023/A:1015773818302 | s2cid = 20719302 }}
• {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | date = Nov 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 | doi-access = free }}
• {{cite journal | vauthors = Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM | title = Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells | journal = Development | volume = 132 | issue = 13 | pages = 3045–54 | date = Jul 2005 | pmid = 15944188 | doi = 10.1242/dev.01890 | doi-access = free }}
• {{cite journal | vauthors = Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F | title = NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY | journal = The Journal of Biological Chemistry | volume = 280 | issue = 46 | pages = 38625–30 | date = Nov 2005 | pmid = 16166090 | doi = 10.1074/jbc.M504127200 | doi-access = free }}
• {{cite journal | vauthors = DesGroseilliers M, Fortin F, Lemyre E, Lemieux N | title = Complex mosaicism in sex reversed SRY+ male twins | journal = Cytogenetic and Genome Research | volume = 112 | issue = 1–2 | pages = 176–9 | year = 2006 | pmid = 16276109 | doi = 10.1159/000087532 | s2cid = 43826181 }}

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• {{PDBe-KB2|P35716|Human Transcription factor SOX-11}}

{{Transcription factors|g4}}

Category:Transcription factors

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