SOX5

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Mutations in the SOX5 gene can cause Lamb-Shaffer syndrome.

• SOX genes

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• {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends in Genetics | volume = 16 | issue = 4 | pages = 182–7 | date = Apr 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
• {{cite journal | vauthors = Bowles J, Schepers G, Koopman P | title = Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators | journal = Developmental Biology | volume = 227 | issue = 2 | pages = 239–55 | date = Nov 2000 | pmid = 11071752 | doi = 10.1006/dbio.2000.9883 | doi-access = free }}
• {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 4 | pages = 441–6 | date = Aug 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
• {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = Aug 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X | doi-access = free }}
• {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Research | volume = 20 | issue = 11 | pages = 2887 | date = Jun 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}
• {{cite journal | vauthors = Connor F, Cary PD, Read CM, Preston NS, Driscoll PC, Denny P, Crane-Robinson C, Ashworth A | title = DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5 | journal = Nucleic Acids Research | volume = 22 | issue = 16 | pages = 3339–46 | date = Aug 1994 | pmid = 8078769 | pmc = 523727 | doi = 10.1093/nar/22.16.3339 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Lefebvre V, Li P, de Crombrugghe B | title = A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene | journal = The EMBO Journal | volume = 17 | issue = 19 | pages = 5718–33 | date = Oct 1998 | pmid = 9755172 | pmc = 1170900 | doi = 10.1093/emboj/17.19.5718 }}
• {{cite journal | vauthors = Uusitalo H, Hiltunen A, Ahonen M, Gao TJ, Lefebvre V, Harley V, Kähäri VM, Vuorio E | title = Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing | journal = Journal of Bone and Mineral Research | volume = 16 | issue = 10 | pages = 1837–45 | date = Oct 2001 | pmid = 11585348 | doi = 10.1359/jbmr.2001.16.10.1837 | s2cid = 42947355 | doi-access = free }}
• {{cite journal | vauthors = Zafarana G, Gillis AJ, van Gurp RJ, Olsson PG, Elstrodt F, Stoop H, Millán JL, Oosterhuis JW, Looijenga LH | title = Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation | journal = Cancer Research | volume = 62 | issue = 6 | pages = 1822–31 | date = Mar 2002 | pmid = 11912161 }}
• {{cite journal | vauthors = Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S | title = Identification and characterization of the human long form of Sox5 (L-SOX5) gene | journal = Gene | volume = 298 | issue = 1 | pages = 59–68 | date = Sep 2002 | pmid = 12406576 | doi = 10.1016/S0378-1119(02)00927-7 }}

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{{Transcription factors|g4}}

Category:Transcription factors

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