SOX8
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.{{cite journal | vauthors = Pfeifer D, Poulat F, Holinski-Feder E, Kooy F, Scherer G | title = The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome | journal = Genomics | volume = 63 | issue = 1 | pages = 108–16 |date=Apr 2000 | pmid = 10662550 | doi = 10.1006/geno.1999.6060 }}{{cite journal | vauthors = Schepers GE, Bullejos M, Hosking BM, Koopman P | title = Cloning and characterisation of the Sry-related transcription factor gene Sox8 | journal = Nucleic Acids Res | volume = 28 | issue = 6 | pages = 1473–80 |date=Apr 2000 | pmid = 10684944 | pmc = 111037 | doi =10.1093/nar/28.6.1473 }}{{cite web | title = Entrez Gene: SOX8 SRY (sex determining region Y)-box 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30812}}
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ATR-16 syndrome).
See also
References
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Further reading
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- {{cite journal |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 |doi-access=free }}
- {{cite journal |vauthors=Cheng YC, Lee CJ, Badge RM, etal |title=Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours |journal=Brain Res. Mol. Brain Res. |volume=92 |issue= 1–2 |pages= 193–200 |year= 2001 |pmid= 11483257 |doi=10.1016/S0169-328X(01)00147-4 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 }}
- {{cite journal | vauthors=Schepers G, Wilson M, Wilhelm D, Koopman P |title=SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28101–8 |year= 2003 |pmid= 12732652 |doi= 10.1074/jbc.M304067200 |doi-access= free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16 |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 |bibcode=2004Natur.432..988M |s2cid=4362044 |url= https://digital.library.unt.edu/ark:/67531/metadc788092/m2/1/high_res_d/842679.pdf |doi-access= free }}
- {{cite journal |vauthors=Wissmüller S, Kosian T, Wolf M, etal |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735–44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 | pmc=1421504 }}
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{{Transcription factors|g4}}
Category:Transcription factors
{{gene-16-stub}}