SPDYA
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Speedy protein A is a protein that in humans is encoded by the SPDYA gene.{{cite journal | vauthors = Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ | title = Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2 | journal = The Journal of Cell Biology | volume = 157 | issue = 3 | pages = 357–66 | date = Apr 2002 | pmid = 11980914 | pmc = 2173287 | doi = 10.1083/jcb.200109045 }}{{cite journal | vauthors = Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ | title = Human Spy1 promotes survival of mammalian cells following DNA damage | journal = Cancer Research | volume = 63 | issue = 13 | pages = 3701–7 | date = Jul 2003 | pmid = 12839962 }}{{cite journal | vauthors = Cheng A, Xiong W, Ferrell JE, Solomon MJ | title = Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins | journal = Cell Cycle | volume = 4 | issue = 1 | pages = 155–65 | date = Jan 2005 | pmid = 15611625 | doi = 10.4161/cc.4.1.1347 | doi-access = free }}{{cite web | title = Entrez Gene: SPDYA speedy homolog A (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=245711}}
Interactions
SPDYA has been shown to interact with CDKN1B.{{cite journal | vauthors = Porter LA, Kong-Beltran M, Donoghue DJ | title = Spy1 interacts with p27Kip1 to allow G1/S progression | journal = Molecular Biology of the Cell | volume = 14 | issue = 9 | pages = 3664–74 | date = Sep 2003 | pmid = 12972555 | pmc = 196558 | doi = 10.1091/mbc.E02-12-0820 }}
References
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Further reading
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- {{cite journal | vauthors = Porter LA, Kong-Beltran M, Donoghue DJ | title = Spy1 interacts with p27Kip1 to allow G1/S progression | journal = Molecular Biology of the Cell | volume = 14 | issue = 9 | pages = 3664–74 | date = Sep 2003 | pmid = 12972555 | pmc = 196558 | doi = 10.1091/mbc.E02-12-0820 }}
- {{cite journal | vauthors = Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ | title = Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation | journal = The Journal of Biological Chemistry | volume = 281 | issue = 46 | pages = 35425–35 | date = Nov 2006 | pmid = 16951407 | doi = 10.1074/jbc.M604720200 | doi-access = free }}
- {{cite journal | vauthors = McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ | title = Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27 | journal = Cell Cycle | volume = 6 | issue = 15 | pages = 1937–45 | date = Aug 2007 | pmid = 17671428 | doi = 10.4161/cc.6.15.4520 | doi-access = free }}
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