SPF

• Sun protection factor, of sunscreen
• Specific-pathogen-free, laboratory animals known to be without pathogens
• Superplastic forming, of sheet metal
• Space Power Facility, a NASA test facility
• S-phase-promoting factor, in biology
• Formal spectrum of a ring, a construction in algebraic geometry
• Spray polyurethane foam, a building insulation material
• Spruce-pine-fir, mixed softwood timber
• Spot 42 RNA, a small regulatory RNA found in some Gammaproteobacteria

• Sender Policy Framework, for email authentication
• Shortest Path First, or Dijkstra's algorithm
• IBM Structured Programming Facility, later ISPF

• {{lang|fr|Société des poètes français|italics=no}}, the oldest poetry society in France
• {{lang|es|Servicio Penitenciario Federal|italics=no}}, the Argentine Federal Penitentiary Service
• {{lang|el|Synomosía Pyrínon tis Fotiás|italics=no}} (Conspiracy of Fire Nuclei), Greek terrorist organization

• Scottish Police Federation
• Singapore Police Force
• Somali Police Force
• Special Police Force, a unit within a police force

• Survey of Professional Forecasters, US macroeconomic forecasts survey
• ECB Survey of Professional Forecasters, macroeconomic forecasts

• Security Policy Framework, UK
• Social protection floor
• Annual Summer Play Festival, New York City, US
• Black Hills Airport (IATA airport code), South Dakota, US
• Sherwood Park Freeway, Edmonton, Alberta, Canada
• Springfield railway station (Scotland), station code

• Single point of failure (SPOF)
• Socialist Party of Florida (SPFL)

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