SPHK2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.{{cite web | title = Entrez Gene: Sphingosine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=56848| accessdate = 2011-12-22 }}

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[provided by RefSeq, Aug 2011].

The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.{{Cite journal |last1=Chen |first1=Yanhui |last2=Zhang |first2=Yongrong |last3=Rao |first3=Cheng |last4=Huang |first4=Jieyun |last5=Qing |first5=Qiong |date=2023-03-16 |title=Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation |url=https://www.bjbms.org/ojs/index.php/bjbms/article/view/8034 |journal=Biomolecules and Biomedicine |language=en |volume=23 |issue=2 |pages=259–270 |doi=10.17305/bjbms.2022.8034 |pmid=36226596 |issn=2831-090X|pmc=10113950 }}

Inhibitors

Opaganib

References

{{cite journal | vauthors = Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S | title = Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform | journal = The Journal of Biological Chemistry | volume = 275 | issue = 26 | pages = 19513–20 | date = June 2000 | pmid = 10751414 | doi = 10.1074/jbc.M002759200 | doi-access = free }}
{{cite journal | vauthors = Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA | title = Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 7996–8003 | date = March 2002 | pmid = 11777919 | doi = 10.1074/jbc.M111423200 | doi-access = free }}
{{cite journal | vauthors = Shu X, Wu W, Mosteller RD, Broek D | title = Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases | journal = Molecular and Cellular Biology | volume = 22 | issue = 22 | pages = 7758–68 | date = November 2002 | pmid = 12391145 | pmc = 134718 | doi = 10.1128/mcb.22.22.7758-7768.2002 }}
{{cite journal | vauthors = Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S | title = The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2 | journal = FEBS Letters | volume = 554 | issue = 1–2 | pages = 189–93 | date = November 2003 | pmid = 14596938 | doi = 10.1016/S0014-5793(03)01168-2 | s2cid = 41465940 | doi-access = free }}
{{cite journal | vauthors = Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S | title = Role of sphingosine kinase 2 in cell migration toward epidermal growth factor | journal = The Journal of Biological Chemistry | volume = 280 | issue = 33 | pages = 29462–9 | date = August 2005 | pmid = 15951439 | doi = 10.1074/jbc.M502922200 | doi-access = free }}
{{cite journal | vauthors = Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S, Nakamura S | title = Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis | journal = The Journal of Biological Chemistry | volume = 280 | issue = 43 | pages = 36318–25 | date = October 2005 | pmid = 16103110 | doi = 10.1074/jbc.M504507200 | doi-access = free }}
{{cite journal | vauthors = Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J | title = IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses | journal = The Journal of Biological Chemistry | volume = 281 | issue = 5 | pages = 2515–25 | date = February 2006 | pmid = 16316995 | doi = 10.1074/jbc.M508931200 | doi-access = free }}
{{cite journal | vauthors = Sun J, Yan G, Ren A, You B, Liao JK | title = FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1 | journal = Circulation Research | volume = 99 | issue = 5 | pages = 468–76 | date = September 2006 | pmid = 16888242 | pmc = 2614439 | doi = 10.1161/01.RES.0000239410.65551.b3 }}
{{cite journal | vauthors = Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S | title = Sphingosine kinase type 2 activation by ERK-mediated phosphorylation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 16 | pages = 12058–65 | date = April 2007 | pmid = 17311928 | doi = 10.1074/jbc.M609559200 | doi-access = free }}
{{cite journal | vauthors = Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S | title = Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2 | journal = The Journal of Biological Chemistry | volume = 282 | issue = 37 | pages = 27493–502 | date = September 2007 | pmid = 17635916 | doi = 10.1074/jbc.M701641200 | doi-access = free }}

Category:EC 2.7.1

SPHK2

Inhibitors

References

Further reading