SPINK6
{{Short description|Mammalian protein found in Homo sapiens}}
Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.
See also
References
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{{cite journal |author1=Furio L |author2=Hovnanian A. | title = When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition. | journal = J Invest Dermatol | volume = 131 | issue = 11 | pages = 2169–73 |date=November 2011 | pmid = 21997416 | doi = 10.1038/jid.2011.295 | doi-access = free }}
{{cite journal |author1=Meyer-Hoffert U |author2=Wu Z |author3=Kantyka T |author4=Fischer J |author5=Latendorf T |author6=Hansmann B |author7=Bartels J |author8=He Y |author9=Gläser R |author10=Schröder JM. | title = Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. | journal = J Biol Chem | volume = 285 | issue = 42 | pages = 32174–81 |date=October 2010 | pmid = 20667819 | pmc = 2952218| doi = 10.1074/jbc.M109.091850 |doi-access=free }}
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