SPIRE1

SPIRE1 is a protein that interacts with actin monomers and actin nucleating formin proteins.{{Cite web|url=https://www.uniprot.org/uniprot/Q08AE8|title=SPIRE1 - Protein spire homolog 1 - Homo sapiens (Human) - SPIRE1 gene & protein|website=www.uniprot.org}} SPIRE1 was first identified in Drosophila melanogaster.{{Cite journal|title=cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo|first1=L. J.|last1=Manseau|first2=T.|last2=Schüpbach|date=September 19, 1989|journal=Genes & Development|volume=3|issue=9|pages=1437–1452|doi=10.1101/gad.3.9.1437|pmid=2514120|doi-access=free}} SPIRE1 contains an N-terminal KIND domain which binds formins and four actin-binding WH2 domains which nucleate actin filaments.{{Cite journal|last1=Quinlan|first1=Margot E.|last2=Heuser|first2=John E.|last3=Kerkhoff|first3=Eugen|last4=Mullins|first4=R. Dyche|date=2005-01-27|title=Drosophila Spire is an actin nucleation factor|url=https://pubmed.ncbi.nlm.nih.gov/15674283/|journal=Nature|volume=433|issue=7024|pages=382–388|doi=10.1038/nature03241|issn=1476-4687|pmid=15674283|bibcode=2005Natur.433..382Q |s2cid=4424757 }}{{Cite journal|last1=Vizcarra|first1=Christina L.|last2=Kreutz|first2=Barry|last3=Rodal|first3=Avital A.|last4=Toms|first4=Angela V.|last5=Lu|first5=Jun|last6=Zheng|first6=Wei|last7=Quinlan|first7=Margot E.|last8=Eck|first8=Michael J.|date=2011-07-19|title=Structure and function of the interacting domains of Spire and Fmn-family formins|journal=Proceedings of the National Academy of Sciences|volume=108|issue=29|pages=11884–11889|doi=10.1073/pnas.1105703108 |pmid=21730168 |pmc=3141961 |bibcode=2011PNAS..10811884V |doi-access=free }}